Substituted benzothienyl-pyrrolotriazines and uses thereof

A compound of formula (I)

• wherein
• R1 is hydrogen, chloro, methyl or methoxy,
• R2 is hydrogen or methoxy,
• with the proviso that at least one of R1 and R2 is other than hydrogen, and
• G represents the group —CH2—OR3, —CH2—NR4R5 or —C(═O)—NR6R7,
• wherein
• R3 is (C1-C6)-alkyl substituted with a residue selected from the group consisting of amino, mono-(C1-C4)-alkylamino, di-(C1-C4)alkylamino, aminocarbonyl, mono-(C1-C4)-alkylaminocarbonyl, di-(C1-C4)-alkylaminocarbonyl and 4- to 6-membered heterocycloalkyl,
• or
• is 4- to 6-membered heterocycloalkyl,
• wherein said 4- to 6-membered heterocycloalkyl groups are optionally substituted with one or two residues independently selected from the group consisting of (C1-C4)-alkyl, oxo, hydroxy, amino and aminocarbonyl,
• R4 is hydrogen or (C1-C4)-alkyl,
• R5 is (C1-C6)-alkyl substituted with one or two residues independently selected from the group consisting of hydroxy, (C1-C4)-alkoxy, amino, mono-(C1-C4)-alkylamino, di-(C1-C4)alkylamino, hydroxycarbonyl, aminocarbonyl, mono-(C1-C4)alkylaminocarbonyl, di-(C1-C4)-alkylaminocarbonyl, (C1-C4)alkylcarbonylamino, aminocarbonylamino and 4- to 6-membered heterocycloalkyl,
• wherein said 4- to 6-membered heterocycloalkyl is optionally substituted with one or two residues independently selected from the group consisting of (C1-C4)-alkyl, oxo, hydroxy, amino and aminocarbonyl,
• or
• is (C1-C4)-alkylcarbonyl optionally substituted with a residue selected from the group consisting of hydroxy, (C1-C4)-alkoxy, amino, mono-(C1-C4)-alkylamino and di-(C1-C4)-alkylamino,
• or
• is (C3-C6)-cycloalkyl optionally substituted with one or two residues independently selected from the group consisting of (C1-C4)-alkyl, hydroxy, (C1-C4)-alkoxy, amino, mono-(C1-C4)alkylamino and di-(C1-C4)-alkylamino,
• or
• is 4- to 6-membered heterocycloalkyl optionally substituted with one or two residues independently selected from the group consisting of (C1-C4)-alkyl, oxo, hydroxy, amino and aminocarbonyl,
• or
• R4 and R5 are joined and, taken together with the nitrogen atom to which they are attached, form a mono- or bicyclic, saturated, 4- to 10-membered heterocycloalkyl ring which may contain a second ring heteroatom selected from N and O, and which may be substituted with up to three residues independently selected from the group consisting of (C1-C4)-alkyl, oxo, hydroxy, (C1-C4)-alkoxy, amino, mono-(C1-C4)alkylamino, di-(C1-C4)-alkylamino, azetidino, pyrrolidino, piperidino, (C1-C4)-alkylcarbonyl, (C3-C6)-cycloalkylcarbonyl, hydroxycarbonyl, aminocarbonyl, mono-(C1-C4)-alkylaminocarbonyl, di-(C1-C4)alkylaminocarbonyl, thienyl and phenyl,
• wherein the alkyl groups of said (C1-C4)-alkyl, (C1-C4)-alkoxy, mono-(C1-C4)-alkylamino, di-(C1-C4)-alkylamino and (C1-C4)alkylcarbonyl residues, for their part, are optionally substituted with a residue selected from the group consisting of hydroxy, amino and aminocarbonyl,
• and
• wherein said thienyl and phenyl groups are optionally substituted with one or two residues independently selected from the group consisting of fluoro, chloro, cyano, methyl and trifluoromethyl,
• or
• R4 and R5 are joined and, taken together with the nitrogen atom to which they are attached, form an imidazol-1-yl or 1,2,4-triazol-1-yl ring each of which may be substituted with one or two residues independently selected from the group consisting of (C1-C4)-alkyl and cyano,
• R6 is hydrogen,
• R7 is 4- to 6-membered heterocycloalkyl optionally substituted with one or two residues independently selected from the group consisting of (C1-C4)-alkyl, oxo, hydroxy, amino and aminocarbonyl,
• or
• R6 and R7 are joined and, taken together with the nitrogen atom to which they are attached, form a monocyclic, saturated, 4- to 7-membered heterocycloalkyl ring which may contain a second ring heteroatom selected from N and O, and which may be substituted with one or two residues independently selected from the group consisting of (C1-C4)-alkyl, oxo, hydroxy, amino, mono-(C1-C4)-alkylamino, di-(C1-C4)-alkylamino and aminocarbonyl,
• or a pharmaceutically acceptable salt, hydrate and/or solvate thereof.