Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them

A compound selected from those of formula (I):

• wherein:
• A1 and A2, each independently of the other, represent a hydrogen atom, a halogen atom, a linear or branched (C1-C6)polyhaloalkyl group, a linear or branched (C1-C6)alkyl group or a cycloalkyl group;
• T represents a hydrogen atom, a linear or branched (C1-C6)alkyl group optionally substituted by from one to three halogen atoms, a (C1-C4)alkyl-NR1R2 group, or a (C1-C4)alkyl-OR6 group;
• R1 and R2, each independently of the other, represent a hydrogen atom or a linear or branched (C1-C6)alkyl group,
• or R1 and R2 form with the nitrogen atom carrying them a heterocycloalkyl;
• R3 represents a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, a cycloalkyl group, a (C3-C10)cycloalkyl-(C1-C6)alkyl group wherein the alkyl moiety is linear or branched, a heterocycloalkyl group, an aryl group or a heteroaryl group, wherein one or more of the carbon atoms of the preceding groups, or of their possible substituents, may be deuterated;
• R4 represents an aryl group, a heteroaryl group, a cycloalkyl group or a linear or branched (C1-C6)alkyl group, wherein one or more of the carbon atoms of the preceding groups, or of their possible substituents, may be deuterated;
• R5 represents a hydrogen or halogen atom, a linear or branched (C1-C6)alkyl group, or a linear or branched (C1-C6)alkoxy group;
• R6 represents a hydrogen atom or a linear or branched (C1-C6)alkyl group;
• Ra, Rb, Rc and Rd, each independently of the others, represent a hydrogen atom, a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, an aryl group, a heteroaryl group, a halogen atom, a linear or branched (C1-C6)alkoxy group, a hydroxy group, a linear or branched (C1-C6)polyhaloalkyl group, a trifluoromethoxy group, —NR7R7′, nitro, R7—CO—(C0-C6)alkyl-, R7—CO—NH—(C0-C6)alkyl-, NR7R7′—CO—(C0-C6)alkyl-, NR7R7′-CO—(C0-C6)alkyl-O—, R7—SO2—NH—(C0-C6)alkyl-, R7—NH—CO—NH—(C0-C6)alkyl-, R7—O—CO—NH—(C0-C6)alkyl-, a heterocycloalkyl group, or the substituents of one of the pairs (Ra,Rb), (Rb,Rc), or (Rc,Rd) form together with the carbon atoms carrying them a ring composed of from 5 to 7 ring members, which ring may have from one to 2 hetero atoms selected from oxygen and sulphur, wherein one or more carbon atoms of the ring defined hereinbefore may be deuterated or substituted by from one to 3 groups selected from halogen and linear or branched (C1-C6)alkyl;
• R7 and R7′, each independently of the other, represent a hydrogen atom, a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, an aryl group or a heteroaryl group, or R7 and R7′, together with the nitrogen atom carrying them, form a heterocycle composed of from 5 to 7 ring members;
• it being understood that:
• “aryl” means a phenyl, naphthyl, biphenyl or indenyl group,
• “heteroaryl” means any mono- or bi-cyclic group composed of from 5 to 10 ring members, having at least one aromatic moiety and having from 1 to 4 hetero atoms selected from oxygen, sulphur and nitrogen (including quaternary nitrogens),
• “cycloalkyl” means any mono- or bi-cyclic, non-aromatic, carbocyclic group having from 3 to 10 ring members,
• “heterocycloalkyl” means any mono- or bi-cyclic, non-aromatic, condensed or spiro group composed of from 3 to 10 ring members and having from 1 to 3 hetero atoms selected from oxygen, sulphur, SO, SO2 and nitrogen,
• wherein the aryl, heteroaryl, cycloalkyl and heterocycloalkyl groups so defined and the alkyl, alkenyl, alkynyl and alkoxy groups may be optionally substituted by from 1 to 3 groups selected from optionally substituted, linear or branched (C1-C6)alkyl, (C3-C6)spiro, optionally substituted, linear or branched (C1-C6)alkoxy, (C1-C6)alkyl-S—, hydroxy, oxo (or N-oxide where appropriate), nitro, cyano, —COOR′, —OCOR′, NR′R″, linear or branched (C1-C6)polyhaloalkyl, trifluoromethoxy, (C1-C6)alkylsulphonyl, halogen, optionally substituted aryl, heteroaryl, aryloxy, arylthio, cycloalkyl, heterocycloalkyl optionally substituted by one or more halogen atoms or alkyl groups, wherein R′ and R″, each independently of the other, represent a hydrogen atom or an optionally substituted, linear or branched (C1-C6)alkyl group,
• and its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.