Heterocyclic compounds and uses thereof

A compound of Formula (I):

• or its pharmaceutically acceptable forms thereof, wherein:
• W5 is N, CHR4 or CR4;
• R4 is hydrogen, alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, thio, sulfoxide, sulfone, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, or NR′R″ wherein R′ and R″ are taken together with nitrogen to form a cyclic moiety;
• Cy is aryl or heteroaryl substituted by 0-4 occurrences of R3;
• R1 is -(L)n-R1′;
• each L is independently a bond, alkylene, heteroalkylene, —N(R2)—, —S(═O)—, —S(═O)2—, —S—, —C(═O)—, —P(═O)R2—, or —O—;
• R1′ is hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocyclyloxy, heterocycloalkyloxy, amino, amido, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, —(C═O)—NRa1Ra2, or NRa1Ra2;
• Ra1 and Ra2 are each independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, thio, sulfoxide, sulfone, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, or Ra1 and Ra2 are taken together with nitrogen to form a cyclic moiety;
• R2 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, heteroalkyl, aryl, or heteroaryl;
• each R3 is independently alkyl, heteroalkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, thio, sulfoxide, sulfone, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, or NR′R″ wherein R′ and R″ are taken together with nitrogen to form a cyclic moiety;
• X is absent or is —(CH(R10))z—;
• Y is absent, —O—, —S—, —S(═O)—, —S(═O)2—, —N(R9)—, —C(═O)—(CHR10)z—, —C(═O)—, —N(R9)—C(═O)—, —C(═O)—N(R9)—, —N(R9)—C(═O)NH—, —N(R9)C(R10)2—, —C(═O)—(CHR10)z—, —C(═O)—N(R9)—(CHR10)z—, or —P(═O)R2—;
• each z is an integer of 1, 2, 3, or 4;
• n is an integer of 0, 1, 2, 3, or 4;
• each R9 is independently hydrogen, alkyl, cycloalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroalkyl, aryl, or heteroaryl;
• Wd is heterocycloalkyl, aryl, cycloalkyl, or heteroaryl, wherein Wd is optionally substituted with one or more Rb, R11, R12, and R13;
• each Rb is independently hydrogen, halo, phosphate, urea, carbonate, alkyl, alkenyl, alkynyl, cycloalkyl, heteroalkyl, or heterocycloalkyl;
• and
• each R10, R11, R12, and R13 is independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocyclyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, haloalkyl, cyano, hydroxyl, nitro, phosphate, urea, carbonate, or NR′R″ wherein R′ and R″ are taken together with nitrogen to form a cyclic moiety.