Production Of Stabilized Channel Type Cyclodextrin Crystals
AssigneeAmphidex A/S
InventorsKim Lambertsen Larsen, Ronnie Nielsen, Thuy Thanh Do
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Abstract
The present invention relates to stabilized channel type cyclodextrin crystals. In particular the present invention relates to a method for producing stabilized channel type cyclodextrin crystals, stabilized channel type cyclodextrin crystal comprising a stabilizer, uses of said stabilized crystals and products comprising stabilized channel type cyclodextrin crystals.
Claims26
A method for producing channel type cyclodextrin crystals comprising the steps of:
- a) Providing a solution of cyclodextrin further comprising a water-soluble stabilizer with a vapour pressure of less than 1 mmHg at 25 degrees Celsius, and at least 2 hydrogen bond donors and/or acceptors;
- wherein the liquid matter of the solution of cyclodextrin comprises at least 50% w/w of water;
- b) Contacting said solution with a non-solvent system having a Snyder polarity index (P′) of less than 6.6 to precipitate channel type cyclodextrin co-precipitated with said stabilizer;
- c) Separating the precipitated channel type cyclodextrin co-precipitated with said stabilizer from the solution and non-solvent system;
- wherein the molar ratio between cyclodextrin and stabilizer in said solution is at least 1:0.0001.
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A stabilised channel type cyclodextrin crystal comprising a water-soluble stabilizer with a vapour pressure of less than 1 mmHg at 25 degrees Celsius, and at least 2 hydrogen bond donors and/or acceptors, wherein
- provided the channel type crystal is an α-cyclodextrin channel type crystal it is an α-CD channel type crystal characterized by at least the following X-ray powder diffractogram reflexes:
- Angle
- Rel. int
- [°2θ]
- [%]
- 5.61
- 30.82
- 7.45
- 38.5
- 11.17
- 45.9
- 11.13
- 54.3
- 13.80
- 17.2
- 18.66
- 40.3
- 19.78
- 100.0
- or
- provided the channel type crystal is a β-cyclodextrin channel type crystal it is an β-CD channel type crystal characterized by at least the following X-ray powder diffractogram reflexes:
- Angle
- Rel. int
- [°2θ]
- [%]
- 6.21
- 66.4
- 7.24
- 100.0
- 9.74
- 19.7
- 10.09
- 53.2
- 11.96
- 51.3
- 12.22
- 45.5
- 18.80
- 43.8
- or
- provided the channel type crystal is a γ-cyclodextrin channel type crystal it is an γ-CD channel type crystal characterized by at least the following X-ray powder diffractogram reflexes:
- Angle
- Rel. int
- [[°2θ]
- [%]
- 5.28
- 62.0
- 7.47
- 100.0
- 10.59
- 11.4
- 12.13
- 8.0
- 14.29
- 8.1
- 14.98
- 10.6
- 15.88
- 11.7
- 16.73
- 14.8
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27-35. (canceled)
Dependencies are inferred from the claim text.