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US 2015/0030699 A1Published application
Anti-tumor adjuvant therapy
AssigneesUniversite Pierre Et Marie Curie (Paris 6), Institute Curie
InventorsAngelita Rebollo Garcia, Fariba Nemati, Didier Decaudin
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Abstract
The invention relates to a chimeric peptide construct comprising a cell penetrating peptide linked to a pro-apoptotic peptide, for use in treating a tumor in combination with an anti-tumor agent, preferably a chemotherapeutic agent.
Claims21
A chimeric peptide construct comprising a cell penetrating peptide linked to a pro-apoptotic peptide, for use in treating a tumor in combination with an anti-tumor agent, wherein the pro-apoptotic peptide comprises sequence is:
- (SEQ ID NO:
- 3)
- Y-X4a-ETLD-X4b-I-X5-EQWA-X6-S-X7
- wherein
- X4a is valine or isoleucine;
- X4b is aspartic acid or glycine;
- X5 is phenylalanine or leucine;
- X6 is arginine or histidine;
- X7 is vacant or is glutamate, or glutamate-aspartate, or glutamate-aspartate-leucine;
- or
- a proteolysis-resistant peptide deriving from said pro-apoptotic peptide by one or more chemical modifications, or a substantially homologous peptide, preferably deriving from SEQ ID NO:
- 3 by one or more conservative substitutions,
9 more elements
(canceled)
Dependencies are inferred from the claim text.