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US 2015/0030656 A1Published application
Composition and Method for Delivery of BMP-2 Amplifier/Co-Activator for Enhancement of Osteogenesis
AssigneeBioSurface Engineering Technologies, Inc.
InventorsPaul Zamora, Brent Lee Atkinson, Xinhua Lin, Louis A. Pena
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Abstract
A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.
Claims24
A composition comprising:
- a synthetic growth factor analoge comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor, and
- an osteoconductive material comprising one or more of an inorganic material, a synthetic polymer, a natural polymer, an allograft bone, or combination thereof,
- wherein the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.
A kit comprising:
- a lyophilized vial of synthetic growth factor analogue (with or without excipients);
- and a container of osteoconductive material.
Dependencies are inferred from the claim text.