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US 2015/0030539 A1Published application
Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system or of tumors
AssigneePiramal Imaging SA
InventorsLutz LEHMANN, Andrea THIELE, Tobias HEINRICH, Thomas BRUMBY, Christer HALLDIN, Balazs GULYAS, Sangram NAG
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Abstract
This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).
Claims40
A compound of formula Ib
- wherein
- W is
- —C(U1)(U2)—C≡CH,
- U1 and U2 are each being independently selected from hydrogen and deuterium,
- G3 is hydrogen,
- G4 is L,
- L is a leaving group, or L is F,
- n is an integer from 0 to 6, and
- e and f are each independently an integer from 0 to 1, with the proviso that at least one of e and f is 1,
- including all isomeric forms of said compound, including but not limited to enantiomers and diastereoisomers as well as racemic mixtures,
- and any pharmaceutically acceptable salt, ester, amide, complex or prodrug thereof.
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A compound selected from:
Dependencies are inferred from the claim text.