Cu-Mediated Annulation for the Production of 1-Amino-2-Naphthalenecarboxylic Acid Derivatives
AssigneeCouncil of Scientific and Industrial Research
InventorsSanthosh Rekula Reddy, Kishore Prasad Pragati, Brij Bhushan Ahuja, Arumugam Sudalai
Life of this patent
Estimating the term…
Abstract
Invention provides a cheaper and practical protocol for the construction of a wide variety of 1-Amino-2-naphthalene-carboxylic acid derivatives and their structural analogues that proceeds with high yields in a single step via intramolecular cascade cyano ene reaction.
Claims10
A one pot process for the preparation of compound of formula (A) and their structural analogues comprising reacting compound of formula (B) with CuCN in solvent at a temperature in the range of 145°-155° C. for period in the range of 10 to 12 hours;
- Wherein,
- R1, R2, R3, R4 are selected independently from the group consisting of hydrogen, alkyl, alkoxy, halo, NO2 or CN;
- R5 is selected independently from the group consisting of H, CH3, C2H5, Ph or CH3C6H4;
- R6 is selected independently from the group consisting of CO2Et, CO2Me, CO2Ph, COMe, COPh, CN, SO2Ph, CONH2 or NO2;
- R7 is selected independently from the group consisting of H, CH3 of Ph;
- and
- X represents halo group.
A compound of formula (A)
- Wherein,
- R1, R2, R3, R4 are selected independently from hydrogen, alkyl, alkoxy, halo, NO2, CN;
- R5 is selected independently from H, CH3, C2H5, Ph, CH3C6H4;
- R6 is selected independently from CO2Et, CO2Me, CO2Ph, COMe, COPh, CN, SO2Ph, CONH2, NO2 and
- R7 is selected independently from H, CH3, Ph.
Dependencies are inferred from the claim text.