Bioengineered Allogeneic Blood Vessel
AssigneeNovahep AB
InventorsSuchitra Sumitran-Holgersson, Michael Olausson
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Abstract
The present invention relates to methods for recellularization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells. The allogeneic veins produced by the methods disclosed herein are particularly advantageous for implantation or transplantation into patients with vascular diseases.
Claims33
A method of recellularizing a blood vessel comprising introducing a population of cells to a decellularized blood vessel and culturing said population of cells on the decellularized blood vessel, thereby recellularizing the blood vessel.
A blood vessel produced by any one of the preceding claims.
A method for providing a blood vessel graft to a patient comprising
- a. delivering a subject-derived population of cells to a decellularized blood vessel;
- and
- b. culturing said subject-derived population of cells on the decellularized blood vessel.
Dependencies are inferred from the claim text.