Methods of viewing and analyzing high content biological data
AssigneeGeneral Electric Company
InventorsJohn Frederick Graf, Brion Daryl Sarachan, Maria Ildiko Zavodszky, Lee Aaron Newberg, Chinnappa Dilip Kodira
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Abstract
The invention relates generally to a method for interactive viewing and analysis of high content data in a biological pathway context. The high content data maybe related to the expression of biomarkers within a tissue, cellular, or cellular compartment of individual cell such that the data may reveal patterns of expression to identify a biological process, a clinical diagnosis or prognosis.
Claims20
A computer-implemented method for analysis of high content data in a biological pathway, the method comprising:
- a. identifying one or more dataset comprising high content data entries, where in the high content data entries representative of a biological expression or morphological feature;
- b. selecting one or more of the high content data entries and its corresponding spatial location, within the dataset;
- c. identifying one or more pathway maps comprising pathway data entries, representative of one or more biological pathways;
- d. selecting one or more of the pathway data entries and its corresponding location within the pathway map;
- e. analyzing the high content dataset entries in reference to the pathway data entries to identify one or more correlations;
- f. optionally viewing the high content data within the context of at least one of signal transduction, gene regulation, and metabolic pathway.
A computer system for determining analysis of high content data in a biological pathway, the system comprising:
- a storage device;
- and
- a processor configured to:
- a. identify one or more dataset comprising high content data entries, where in the high content data entries representative of a biological expression or morphological feature;
- b. select one or more of the high content data entries and its corresponding spatial location, within the dataset;
- c. identify one or more pathway maps comprising pathway data entries, representative of one or more biological pathways;
- d. select one or more of the pathway data entries and its corresponding location within the pathway map;
- e. analyze the high content dataset entries in reference to the pathway data entries to identify one or more correlations;
- f. optionally view the high content data within the context of at least one of signal transduction, gene regulation, and metabolic pathway.
One or more computer-readable media having encoded thereon one or more computer-executable instructions for analysis of high content data in a biological pathway, the instructions comprising a method for:
- a. identifying one or more dataset comprising high content data entries, where in the high content data entries representative of a biological expression or morphological feature;
- b. selecting one or more of the high content data entries and its corresponding spatial location, within the dataset;
- c. identifying one or more pathway maps comprising pathway data entries, representative of one or more biological pathways;
- d. selecting one or more of the pathway data entries and its corresponding location within the pathway map;
- e analyzing the high content dataset entries in reference to the pathway data entries to identify one or more correlations;
- f. optionally viewing the high content data within the context of at least one of signal transduction, gene regulation, and metabolic pathway.
Dependencies are inferred from the claim text.