Cabazitaxel, related compounds and methods of synthesis
AssigneeShanghai Bioman Phama Limited
InventorsYunman Zheng, Tianhui Xu, Ragina Naidu
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Abstract
The invention provides new cabazitaxel isoserine ester intermediates and new synthetic methods, and a preparation method for the anti-tumour drugs cabazitaxel, docetaxel and paclitaxel from the new cabazitaxel isoserine intermediates.
Claims21
1-35. (canceled)
A compound having the following formula:
- or a salt thereof, wherein R1 is a hydroxy protecting group and wherein each X is independently either hydrogen, trichloroethoxycarbonyl (TROC) or a straight chain or branched alkyl group, preferably selected from the group consisting of methyl, ethyl, propyl and butyl.
A method of preparing a taxane product compound from a protected taxane intermediate having at least one protecting group, for example trichloroethoxycarbonyl (TROC), the method comprising reacting the protected taxane intermediate with a reducing agent and a Lewis acid to substitute the at least one protecting group with a hydroxyl group.
Dependencies are inferred from the claim text.