US 2014/0371460 A1Published application

Glucosylceramide synthase inhibitors

AssigneeGenzyme Corporation

InventorsElyse BOURQUE, Cassandra CELATKA, Bradford HIRTH, Markus METZ, Zhong ZHAO, Renato SKLERJ, Yibin XIANG, Katherine JANCSICS, John MARSHALL, Seng CHENG, Ronald SCHEULE, Mario CABRERA-SALAZAR, Andrew GOOD

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Abstract

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Claims3

Dependent claims

1-255. (canceled)

Dependencies are inferred from the claim text.

Facts

Application: 14/471,958Filed 28 Aug 2014
Priority: 18 Mar 2011
Published: 18 Dec 2014
Term ends: Not estimatedThe source records don’t support an estimate.

Classification31 codes

C07D 487/08
In which the condensed system contains two hetero rings: bridged systems
A61K 31/439
Having six-membered rings with one nitrogen as the only ring hetero atom: the ring forming part of a bridged ring system, e.g. quinuclidine
A61K 31/454
Containing further heterocyclic ring systems: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/46
Having six-membered rings with one nitrogen as the only ring hetero atom: 8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine

Family

Application61/454,034Us provisional application · filed 18 Mar 2011
Application61/590,711Us provisional application · filed 25 Jan 2012
Application14/030,725Continuation · filed 18 Sep 2013
Application14/471,958Continuation
US 2014/0255381 A1Published application
US 9,126,993 B2Related patent
US 9,139,580 B2Related patent
US 2014/0371460 A1This patent

From the US filing history. Foreign family members aren’t listed.

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