Processes for preparing isoquinolinones and solid forms of isoquinolinones

A method of preparing a compound of Formula (I)

• wherein the compound of Formula (I) is polymorph Form B, Form C, Form D, Form E, Form F, Form G, Form H, Form I, or Form J, or a salt, solvate, or hydrate thereof;
• or a mixture of two or more thereof;
• wherein the method comprises:
• (i) combining a compound of Formula (Ia):
• wherein
• PG2 is a protecting group selected from methylsulfonyl, substituted methylsulfonyl, benzenesulfonyl, substituted benzenesulfonyl, benzyloxycarbonyl, substituted benzyloxycarbonyl, 2,2,2,-trichloroethoxycarbonyl, 2-trimethylsilylethoxycarbonyl, t-butoxycarbonyl, 1-adamantyloxycarbonyl, 2-adamantyloxycarbonyl, alkyl, substituted alkyl, t-butyldimethylsilyl, triisopropylsilyl, allyl, benzyl, substituted benzyl, hydroxymethyl, methoxymethyl, diethoxymethyl, (2-chloroethoxy)methyl, t-butoxymethyl, t-butyldimethylsiloxymethyl, pivaloyloxymethyl, benzyloxymethyl, dimethylaminomethyl, 2-tetrahydropyranyl, substituted alkoxymethyl and substituted aryloxymethyl, and
• where substituents are selected from alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, cycloalkoxy, heterocyclyloxy, aryloxy, heteroaryloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, ester, ether, thio, sulfinyl, sulfonyl, sulfonamido, halo, cyano, hydroxyl, nitro, phosphate, urea, carbamate, and carbonate.
• with one or more reagents to remove the protecting group PG2 to form the compound of Formula (I);
• and
• (ii) recovering the compound of Formula (I) under conditions suitable to provide Form B, Form C, Form D, Form E, Form F, Form G, Form H, Form I, or Form J, or a salt, solvate, or hydrate thereof;
• or a mixture of two or more thereof, of the compound of Formula (I).

A method of preparing polymorph Form C of a compound of Formula (I):

• wherein the method comprises:
• (i) preparing a first slurry of polymorph Form C in dichloromethane;
• (ii) recovering the solids in the first slurry by filtration;
• (iii) preparing a second slurry of the solids recovered in step ii) in water;
• and
• (iv) recovering the solids in the second slurry by filtration to give polymorph Form C.