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US 2014/0371423 A1Published application
Method for purification of micafungin
AssigneeXellia Pharmaceuticals Aps
InventorsLene Aassveen, Eli Karin Dale, Espen Fridtjof Hansen, Kjersti Meldahl Eide
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Abstract
The present invention relates to a method for the purification of Micafungin.
Claims27
A method for producing a pharmaceutically acceptable Micafungin salt comprising the steps of:
- a) applying a Micafungin starting material to a hydrophobic adsorbent resin support;
- b) exposing the bound Micafungin to an aqueous solution of a dissolved pharmaceutically acceptable salt;
- c) eluting the dissolved pharmaceutically acceptable salt of Micafungin with a solution comprising a water miscible organic solvent;
- provided that at least one of
- i) the starting material in step a)
- ii) or the aqueous solution in step b)
- comprises a water miscible organic solvent.
4 more elements
A method for producing a pharmaceutically acceptable Micafungin salt comprising the steps of:
- a) applying a Micafungin starting material to a hydrophobic adsorbent resin support;
- b) exposing the bound Micafungin to an aqueous solution of a dissolved pharmaceutically acceptable salt;
- c) optionally exposing the bound salt of Micafungin obtained in b) to an aqueous solution comprising a water miscible organic solvent one or more times for the removal of impurities;
- d) eluting the dissolved pharmaceutically acceptable salt of Micafungin with a solution comprising a water miscible organic solvent;
- provided that when step c) is not performed, then the Micafungin starting material and/or the aqueous solution in step b) comprises a water miscible organic solvent.
2 more elements
(canceled)
Dependencies are inferred from the claim text.