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AssigneeDermira, Inc.
InventorsJohn Allan STATLER, Anthony Adrian SHAW, Delphine Caroline IMBERT, Jennifer Leigh NELSON, Patricia ANDRES, Lisa Lynn McQUEEN, Stephan Xander Mattheus BOERRIGTER, Jon Gordon SELBO, Mark Christopher ANDRES
Estimating the term…
Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including formulations such as topicals thereof, and methods of treating hyperhidrosis with salts of glycopyrrolate, and formulations such as topicals thereof, are disclosed.
-239. (canceled)
A pharmaceutically acceptable solution comprising a racemic mixture of (R)-3-((S)-2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidinium 4-methylbenzenesulfonate and (S)-3-((R)-2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidinium 4-methylbenzenesulfonate or a solvate thereof, and at least one pharmaceutically acceptable additive, wherein the pH of said pharmaceutically acceptable solution is between 3.5 and 5.5.
A topical composition comprising a glycopyrrolate tosylate comprising a racemic mixture of (R)-3-(S)-2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidinium 4-methylbenzenesulfonate and (S)-3-(R)-2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidinium 4-methylbenzenesulfonate or a solvate thereof, and at least one pharmaceutically acceptable additive, wherein the pH of said topical is between 3.5 and 5.5.
An absorbent pad containing an aqueous glycopyrrolate solution comprising a racemic mixture of (R)-3-(S)-2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidinium 4-methylbenzenesulfonate and (S)-3-(R)-2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidinium 4-methylbenzenesulfonate or a solvate thereof, about 0.15% by weight anhydrous citric acid, about 0.06% sodium citrate dihydrate by weight, and between about 57 to about 59.5% by weight of dehydrated ethanol, wherein said glycopyrrolate solution comprises between about 1% and about 6% by weight glycopyrrolate tosylate and the pH said aqueous glycopyrrolate solution is between 3.5 and 5.5.
Dependencies are inferred from the claim text.