Heteroaryl derivatives as cftr modulators

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• Ar1 is
• Ar1 is optionally substituted with w occurrences of —W—RW;
• wherein
• W is independently a bond or an optionally substituted (C1-C6) alkylidene chain wherein up to two methylene units of W are independently replaced by —CO—, —O—, —S—, —SO2—, or —NR′—;
• R′ is independently H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl;
• and
• RW is independently H, halo, CN, NO2, NH2, CF3, OCF3, OH, alkoxy, or an optionally substituted aliphatic, cycloaliphatic, heterocyclic, aryl, or heteroaryl, wherein, when substituted, Rw is substituted with up to two R2;
• R2 is halo, CN, NO2, CF3, OCF3, OR, —(C1-C6)alkylidene-OH, —(C1-C6)alkylidene-N(R)2, OC(O)R, OC(O)N(R)2, SR, S(O)R, SO2R, SO2N(R)2, SO3R, C(O)R, CO2R, C(O)N(R)2, N(R)2, NRC(O)R, NRCO2R, NRC(O)N(R)2, NRSO2R, B(OR)2, or NRSO2N(R)2;
• R is independently H, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl;
• RN is H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl;
• A is an optionally substituted 3-7 membered monocyclic ring;
• B is optionally fused to a 5-7 membered ring selected from the group consisting of cycloaliphatic, aryl, heterocyclic, and heteroaryl;
• J is selected from the group consisting of CH2, CF2, C(CH3)2, C(O),
• C(Phenyl)2, B(OH), and CH(OEt);
• and
• w is independently an integer from 0 to 5 inclusive;
• provided that when Ar1 is
• W is independently an optionally substituted (C1-C6) alkylidene chain wherein up to two methylene units of W are independently replaced by —CO—, —O—, —S—, —SO2—, or —NR′—.