Substituted piperidinyl-pyridazinyl derivatives useful as scd 1 inhibitors

A compound of formula (I)

• wherein
• R1 is selected from the group consisting of
• a is an integer from 0 to 3;
• each R2 is independently selected from the group consisting of halogen, C1-4alkyl, C1-4alkoxy, halogenated C1-2alkyl, and halogenated C1-2alkoxy;
• R3 is selected from the group consisting of
• wherein R4 is selected from the group consisting of hydrogen, halogen, C1-4alkyl, halogenated C1-2alkyl, —C1-2alkyl-OH, C1-4alkoxy, halogenated C1-2alkoxy, —C1-2alkyl-O—C1-2alkyl, —CO2H, —C(O)O—C1-4alkyl, —C1-2alkyl-C(O)O—C1-2alkyl, —C1-2alkyl-OC(O)—C1-2alkyl, —NRARB, —C1-2alkyl-NRARB, —C(O)—NRARB, —C1-2alkyl-C(O)—NRARB and —NRA—C(O)—(C1-2alkyl);
• wherein R5 is selected from the group consisting of hydrogen, C1-4alkyl, —C2-4alkyl-OH, —C2-3alkyl-O—C1-2alkyl, —C1-2alkyl-C(O)O—C1-2alkyl, —C2-3alkyl-OC(O)—C1-2alkyl, —C2-4alkyl-NRARB and —C1-2alkyl-C(O)NRARB;
• and
• wherein b is an integer from 0 to 2;
• wherein each R6 is independently selected from the group consisting of halogen, C1-4alkyl, halogenated C1-4alkyl, —C1-2alkyl-OH, C1-4alkoxy, halogenated C1-4alkoxy, —C1-2alkyl-O—C1-2alkyl, —CO2H, —C(O)O—C1-4alkyl, —C1-2alkyl-C(O)O—C1-2alkyl, —C1-2alkyl-OC(O)—C1-2alkyl, —C(O)—NRARB, —C1-2alkyl-C(O)—NRARB, —NRARB, —C1-2alkyl-NRARB and —NRA—C(O)—C1-2alkyl;
• and wherein RA and RB are each independently selected from the group consisting of hydrogen and C1-2alkyl;
• alternatively RA and RB are taken together with the nitrogen atom to which they are bound to form piperidin-1-yl, piperazin-1-yl, morpholin-4-yl and pyrrolidin-1-yl;
• provided that when R3 is 3-methyl-1,2,4-thiadiazol-5-yl, then R1 is other than unsubstituted indoly-3-yl;
• or a pharmaceutically acceptable salt thereof.