Thieno[3,2-d]pyrimidine derivatives having inhibitory activity for protein kinases

A thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof:

• wherein,
• A is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, 3- to 6-membered heterocycloalkyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein said aryl or heteroaryl is optionally reduced or substituted with hydrogen;
• W is O, S, S(O), S(O)2, NH, —NHNH— or 3- to 6-membered heterocycloalkyl;
• X and Y are each independently CH or N;
• Z is hydrogen, C1-3 alkyl or NR3R4, wherein said R3 and R4 are each independently hydrogen, C1-6 alkyl or —(CH 2)q-B—, B representing NR5R6, C1-6 alkoxy, C3-6 cycloalkyl or 3- to 6-membered heterocycloalkyl;
• R1 is hydrogen, halogen, C1-3 alkyl or C1-3 alkoxy, wherein said alkyl or alkoxy is unsubstituted or substituted with one or more halogen atoms;
• R2 is hydrogen, halogen, —CF3, —NO2, —OH, —CN, C1-6 alkoxy, C1-6 alkyl, C2-4 alkenyl, C2-4 alkynyl, —NR7R8, —NHSO2R9, —SO2R10, —C(O)R11, —NHC(O)R12, —NHC(O)OR13, —S(O)R14, C3-6 cycloalkyl, 5- to 10-membered heterocycloalkyl, C6-10 aryl, C6-10 aryloxy, 5- to 10-membered heteroaryl or 3- to 6-membered heteroaryloxy, wherein said R2 is connected to A by —(CH2)p- or substituted with C1-4 alkyl, C2-4alkynyl, C1-4 alkylcarbonyl or one or more halogen atoms;
• R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are each independently hydrogen, —NH2, C1-6 alkyl, C1-6 alkoxy, C3-6 cycloalkyl or 3- to 6-membered heterocycloalkyl, said alkyl, alkoxy, cycloalkyl or heterocycloalkyl being unsubstituted or substituted with one or more halogen atoms;
• q is an integer ranging from 0 to 3;
• p is an integer ranging from 0 to 3;
• m is an integer ranging from 0 to 5;
• n is an integer ranging from 0 to 2;
• and
• when A is hydrogen, m is 0.