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AssigneeUniversity of Iowa Research Foundation
InventorsChristopher M. Adams, Steven D. Kunkel, Michael Welsh, Scott Ebert
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In an aspect, the invention relates to compositions, methods, and kits for inhibiting or preventing skeletal muscle atrophy or inducing muscle hypertrophy by providing to an animal an effective amount of a composition comprising a Gadd45a and/or Cdkn1a inhibitor and an androgen and/or growth hormone elevator or an androgen and/or growth hormone receptor activator. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
A composition for treating or inhibiting the progression of skeletal muscle atrophy, the composition comprising:
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A method for treating or inhibiting the progression of muscle atrophy in an animal, the method comprising administering to the animal an effective amount of a composition comprising a Gadd45a and/or Cdkn1a inhibitor and an androgen and/or growth hormone elevator or receptor activator.
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A method for activating growth hormone receptor in a mammal, the method comprising administering a composition comprising ursolic acid or an ursolic acid derivative.
A method for facilitating muscle hypertrophy, the method comprising the steps of:
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Dependencies are inferred from the claim text.