Preparation of pna-6-aminoglucosamine conjugates as antiviral agents
OwnerVirendra Pandey, Jean-Luc Decout +2inventors
InventorsVirendra Pandey, Jean-Luc Decout, Indrajit Das, Jerome Desire
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Abstract
The present invention relates to methods and compositions pertaining to conjugates comprising a nucleic acid oligomer conjugated to a glucosamine or a derivative thereof which are useful for inhibiting the transcription of target nucleic acids. The conjugates of the invention exhibit advantageous bioavailability and readily penetrate cell membranes which make them useful for inhibiting translation of target mRNA in vivo.
Claims20
A compound comprising a nucleic acid oligomer and a glucosamine conjugated thereto.
A composition comprising a compound of formula I and a pharmaceutically acceptable carrier or excipient.
A method of treating a disease or disorder in a mammal mediated by a protein or nucleic acid comprising administering to said mammal an effective amount of a conjugate compound of the invention wherein the nucleic acid of the conjugate compound hybridizes to the nucleic acid mediating said disease or disorder or to the nucleic acid encoding the protein mediating said disease or disorder.
Dependencies are inferred from the claim text.