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AssigneeThe General Hospital Corporation
InventorsZdravka Medarova, Mehmet V. Yigit, Anna Moore
Estimating the term…
Provided herein are therapeutic nanoparticles having a diameter of between 10 nm to 30 nm, and containing a polymer coating, and a nucleic acid containing a sequence complementary to a sequence within a micro-RNA identified as having a role in cancer cell metastasis or anti-apoptotic activity in a cancer cell (e.g., miR-10b) or a sequence within an mRNA encoding a pro-apoptotic protein that is covalently linked to the nanoparticle. Also provided are pharmaceutical compositions containing these therapeutic nanoparticles. Also provided herein are methods of decreasing cancer cell invasion or metastasis in a subject having a cancer and methods of treating a metastatic cancer in a lymph node in a subject that require the administration of these therapeutic nanoparticles to a subject.
1-26. (canceled)
A method for reducing the rate of metastatic tumor growth in a subject having a primary tumor or a metastatic tumor, the method comprising:
A method for arresting cancer cell metastasis from a primary tumor or a metastatic tumor in a subject, the method comprising
A method for regressing cancer cell metastasis from a primary tumor or a metastatic tumor in a subject, the method comprising
A method for treating a metastatic cancer in a distant site in a subject, the method comprising:
Dependencies are inferred from the claim text.