Method and Composition for In Situ Formation and/or Expansion of a Polymer-Based Hemostatic Agent to Control Bleeding

An injection method for in situ formation of a pressurized obstruction in a wound or bleeding body cavity to control bleeding, comprising the steps of:

• a) providing a first component comprising hydrogen peroxide having a concentration of about 10% to 20% by volume or weight;
• b) providing a second component comprising an expandable component comprising polyvinylsiloxane;
• c) providing a third component comprising a catalyst comprising platinum;
• d) delivering the first, second and third components by injection into the wound or body cavity;
• e) allowing the catalyst comprising platinum to come in contact with the hydrogen peroxide thereby producing a gas;
• and
• f) allowing the gas to come in contact with the polyvinylsiloxane thereby producing an expanded mass within 5 seconds to 45 seconds forming a pressurized obstruction to control bleeding in the wound or body cavity.

An injection method for in situ formation of a pressurized obstruction in a wound or bleeding body cavity to control bleeding, comprising the steps of:

• a) providing a polymer-forming component comprising polyvinylsiloxane;
• b) providing hydrogen peroxide having a concentration from 16% to 20% by volume or weight;
• c) delivering the polymer-forming component and hydrogen peroxide by injection into the wound or body cavity;
• and
• d) allowing the hydrogen peroxide to come in contact an endogenous or exogenous catalyst comprising platinum, thereby producing an expanded mass within 5 seconds to 45 seconds forming a pressurized obstruction to control bleeding in the wound or body cavity.