Acid resistant banding solution for acid resistant two piece hard capsules
AssigneeCapsugel Belgium NV
InventorsXiongwei He, Dominique Nicolas Cade
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Abstract
The present disclosure relates to acid resistant banding solutions for two piece hard capsules endowed with acid resistant properties, and methods of making and using acid resistant banding solutions. The present disclosure also relates, in part, to methods for banding such acid resistant capsules which provides an acid resistant seal between the capsules parts and achieves increased acid resistance in vitro.
Claims34
An acid resistant banding composition for acid resistant two piece hard capsules, comprising at least one acid resistant polymer, at least one alkaline compound, and water.
An acid resistant banding composition for acid resistant two piece hard capsules, comprising:
- at least one acid resistant polymer selected from the group consisting of hydroxypropyl methylcellulose phthalate (HPMCP), cellulose acetate phthalate (CAP), and hydroxypropyl methylcellulose acetate succinate (HPMCAS);
- ammonia;
- and
- water.
A method for the preparation of an acid resistant banding solution, comprising:
- dispersing at least one acid resistant polymer in water under mixing;
- and
- adding at least one alkaline compound progressively under gentle stirring until the at least one acid resistant polymer is dissolved.
A method for banding an acid resistant hard capsule with an acid resistant banding composition comprising at least one acid resistant polymer, at least one alkaline compound, and water comprising:
- determining the desired banding composition amount;
- measuring the banding composition required;
- and
- applying the banding composition to the acid resistant capsule.
Dependencies are inferred from the claim text.