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US 2014/0350534 A1Published application
Raman based ablation/resection systems and methods
AssigneeSloan-Kettering Institute for Cancer Research
InventorsMoritz Kircher, Ricardo Toledo-Crow
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Abstract
Described herein are methods, systems, and devices for automated laser ablation and/or tissue resection triggered by Raman spectroscopic information. These systems and methods provide for precise removal of cancerous or other diseased tissue with minimal damage to adjacent healthy tissue.
Claims26
A system comprising:
- an excitation light source for directing excitation light onto or into a target tissue;
- an instrument operably linked to the excitation light source, the instrument comprising:
- optics for directing the excitation light onto or into the target tissue;
- a detector for detecting Raman scattered photons emanating from the target tissue, said Raman scattered photons resulting from illumination with the excitation light and
- a resector/ablator mechanism;
- a processor configured to process data corresponding to the Raman scattered photons detected from the target tissue;
- and
- a resector/ablator controller operably linked to the processor and operably linked to the resector/ablator mechanism.
5 more elements
A method of resecting, ablating, and/or destroying diseased tissue, the method comprising:
- positioning an instrument in relation to a first location of a target tissue of a subject, the instrument comprising:
- optics for directing excitation light onto or into the target tissue at a given location;
- a detector for detecting Raman scattered photons emanating from the target tissue at the given location;
- and
- a resector/ablator mechanism;
- detecting the Raman scattered photons emanating from the first location of the target tissue;
- analyzing the detected Raman scattered photons emanating from the first location to determine whether the detected photons are indicative of the presence of a Raman reporter at the first location;
- and
- activating the resector/ablator mechanism to resect the target tissue at the first location only if the analyzed photons from the first location are determined to be indicative of the presence of the Raman reporter at the first location.
6 more elements
A method of resecting, ablating, and/or destroying diseased tissue, the method comprising:
- positioning a resector/ablator instrument in relation to a first location of a target tissue of a subject;
- detecting Raman scattered photons emanating from the first location of the target tissue using the instrument;
- analyzing the detected Raman scattered photons emanating from the first location to determine whether the detected photons are indicative of the presence of a Raman reporter at the first location;
- and
- resecting and/or ablating, via the instrument, the target tissue at the first location only if the analyzed photons from the first location are determined to be indicative of the presence of the Raman reporter at the first location.
2 more elements
Dependencies are inferred from the claim text.