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US 2014/0350529 A1Published application
Sustained Release Capsules
AssigneeMerial Limited
InventorRobert William Lachlan Holmes
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AssigneeMerial Limited
InventorRobert William Lachlan Holmes
Estimating the term…
The invention relates to an intraruminal sustained release capsule which is capable of delivering a sustained release dose of a first medicament to an animal, as well as either or both of a dump dose of a second medicament or mineral, and an exit dose of a third medicament or mineral. The capsule can have a dissolvable overcap moulded from plasticised starch enabling a dump dose of medicament to be held between the overcap and one end of the capsule. A piston within the body of the capsule can be modified to enable it to accommodate an exit dose of medicament within its hollow interior which is aligned with an aperture at the end of the capsule which enables release of the medicaments to the rumen. After insertion of the capsule in the animal the overcap (if present) dissolves and separates from the capsule to release the dump dose of medicament. The sustained release medicament is then dispensed via the apertured end, followed by the release of the exit dose of medicament (if present).
1-13. (canceled)
A sustained release capsule comprising a hollow tubular body sealed at a first end, a movable piston within the body, a spring biasing the piston towards a second end of the body, an apertured cover at the second end to define a first chamber between the movable piston and the apertured cover capable of containing a first dose of material within the hollow tubular body for subsequent sustained release through the apertured cover into a rumen of an animal;
The sustained release capsule of claim 1, where in the overcap is attached to the second end to form a void between the apertured cover and the overcap capable of containing the second dose of material within the void so that in use the second dose of material is delivered to the rumen when the overcap is breached or detaches from the second end of the device.
The sustained release capsule of any one of the preceding claims, wherein the overcap is releasably attached to the device by a dissolvable attachment.
The sustained release capsule of any one of the preceding claims, wherein the overcap is made of a material which will dissolve or breakup in the rumen.
The sustained release capsule of any one of the preceding claims, wherein the overcap is made of a material selected from the group consisting of cellulosic fibre, cardboard, paper, a water soluble plastics material and starch.
The sustained release capsule of any one of the preceding claims, wherein the body has at least one external protrusion adapted in use to assist in retaining the capsule in the rumen of an animal.
The sustained release capsule of claim 6, wherein the at least one protrusion consists of a pair of foldable wings.
The sustained release capsule of any one of the preceding claims, wherein the capsule is loaded with a first dose of material.
The sustained release capsule of any one of the preceding claims, wherein the capsule is loaded with a second dose of material in the overcap.
The sustained release capsule of any one of the preceding claims, wherein the capsule is loaded with an exit dose of material.
The sustained release capsule of claim 9, wherein the second dose of material in the overcap comprises copper needles.
The sustained release capsule of claim 1, wherein the movable piston has an end face facing towards the first dose, a hollow central sleeve extending rearwardly from the end face to assist in locating a spring, an aperture in the end face into the hollow interior of the central sleeve, the central sleeve having a closed portion distal from the end face to create a void capable of containing an exit dose of material.
The sustained release capsule of claim 1 comprising a hollow tubular body sealed at a first end, a movable piston within the body, a spring biasing the piston towards a second end of the body, an apertured cover at the second end to define a first chamber between the movable piston and the apertured cover capable of containing a first dose of material within the hollow tubular body for subsequent sustained release through the apertured cover into the rumen of an animal, wherein the movable piston has an end face facing towards the first dose, a hollow central sleeve extending rearwardly from the end face to assist in locating a spring, an aperture in the end face into the hollow interior of the central sleeve, the central sleeve having a closed portion distal from the end face to create a void capable of containing an exit dose of material, and wherein an overcap is releasably attached to the device at one end thereof to form a void between an end of the device and the overcap capable of containing a second dose of material within the void so that in use the second dose of material is delivered to the rumen when the overcap is breached or detaches from the device.
The sustained release capsule of claim 13, wherein the sustained release capsule contains a dump dose of material within the overcap, a sustained release dose of material within the body of the capsule and an exit dose of material within the piston.
Dependencies are inferred from the claim text.