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US 2014/0350392 A1Published application
Methods of spatial normalization of positron emission tomography images
AssigneeGe Healthcare Limited
InventorsRoger Lundqvist, Lennart Nils Thurfjell, Johan Lilja
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Abstract
An adaptive template image for registering a PET or a SPECT image includes a template image model including variability of values for each voxel in a template image according to one or more control parameters.
Claims30
An adaptive template image for registering a PET or a SPECT image, comprising:
- a template image model comprising the variability of values for each voxel in a template image according to one or more control parameters.
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A method of registering a PET image to an adaptive template image comprising the steps of:
- Spatially normalizing an individual PET image to an adaptive template image located in the reference space;
- Comparing the spatially normalized individual PET image to the adaptive template image to determine whether both are sufficiently converged;
- and
- Altering the parameter controlling the template image and the parameters controlling the spatial transformation for the individual PET image so as render an altered template image and an updated spatially transformed individual PET image in the event that the comparing step does not determine that the spatially normalized individual PET image is sufficiently converged to the adaptive template image.
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A system for registering a PET image to an adaptive template comprising:
- means for transforming a moving image using selected start parameters;
- a source for a template model;
- means for modifying the template model using a control parameter so as to provide an adaptive template;
- means for comparing the transformed moving image with the adaptive template;
- means for selecting new parameters to apply to the transformed image and a new control parameter for the adaptive template;
- means for transforming the transformed moving image using the new parameters;
- means for adjusting the adaptive template using the new template control parameter;
- and
- means for storing the transformed moving image when it has sufficiently converged with the adaptive template.
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A method of constructing an adaptive template comprising the steps of:
- Calculating a mean image from a set of input PET images showing uptake of an imaging agent in a region of interest, the set of input PET images having been transformed into a reference space;
- and
- Calculating a regression model for each voxel in the set of images having been transformed into a reference space, where a dependent variable represents the voxel intensities in the input images and is regressed on some variable which for each input image represents a “true” value of where on a scale from a normal level of uptake to a high level of uptake of the imaging agent the voxel is located.
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A positron emission tomography (PET) system comprising:
- a storage device;
- a detector for detecting positron emissions from a brain of a subject, wherein the detector generates signals representing the positron emissions that are stored in the storage device;
- an image processor for, wherein the image processor is programmed to:
- Spatially normalize an individual PET image to an adaptive template image located in the reference space;
- Compare the spatially normalized individual PET image to the adaptive template image to determine whether both are sufficiently converged;
- and
- Alter the parameter controlling the template image and the parameters controlling the spatial transformation for the individual PET image so as render an altered template image and an updated spatially transformed individual PET image in the event that the comparing step does not determine that the spatially normalized individual PET image is sufficiently converged to the adaptive template image.
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A positron emission tomography (PET) system comprising:
- an image processor for registering a PET image to an adaptive template image that is programmed to:
- Spatially normalize an individual PET image to an adaptive template image located in the reference space;
- Compare the spatially normalized individual PET image to the adaptive template image to determine whether both are sufficiently converged;
- and
- Alter the parameter controlling the template image and the parameters controlling the spatial transformation for the individual PET image so as render an altered template image and an updated spatially transformed individual PET image in the event that the comparing step does not determine that the spatially normalized individual PET image is sufficiently converged to the adaptive template image.
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A computer-implemented method of registering a registering a PET image to an adaptive template image, the method comprising:
- Spatially normalizing an individual PET image to an adaptive template image located in the reference space;
- Comparing the spatially normalized individual PET image to the adaptive template image to determine whether both are sufficiently converged;
- and
- Altering the parameter controlling the template image and the parameters controlling the spatial transformation for the individual PET image so as render an altered template image and an updated spatially transformed individual PET image in the event that the comparing step does not determine that the spatially normalized individual PET image is sufficiently converged to the adaptive template image.
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Dependencies are inferred from the claim text.