Particulate System For Use in Diminishing Cell Growth/Inducing Cell Killing
OwnerPeter Langguth, Karl Buch +2inventors
InventorsPeter Langguth, Karl Buch, Thomas Nawroth, Heinz Schmidberger
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Abstract
The Invention relates to a particulate system for use in diminishing cell growth, in particular the growth of cancer cells, comprising one or more water soluble lanthanide compounds that are embedded in a solid biodegradable polymer particle, the polymer being selected from the group consisting of polycarbonic acids, polylactic acids, polyglycolic acids, polypeptides or combinations thereof.
Claims18
A particulate system for use in diminishing cell growth, comprising one or more water soluble lanthanide compounds that are embedded in a solid biodegradable polymer particle, the polymer being selected from the group consisting of polycarbonic acids, polylactic acids, polyglycolic acids, polypeptides or combinations thereof, wherein the lanthanide compounds of the polymer particles have a photon energy that is greater than 38 keV and a K absorption edge Z that is greater than 56.
A method for diminishing cell growth, comprising the steps of exposing cells to a particulate system, comprising one or more water soluble lanthanide compounds with a photon energy >38 keV and a K absorption edge Z >56 as irradiation enhancer, wherein the lanthanide compounds are embedded in a biodegradable polymer particle as carrier, the polymer being selected from the group consisting of polycarbonic acids, polylactic acids, polyglycolic acids, polypeptides or combinations thereof, and exposing the cells that are treated with the particulate system to irradiation at a wave length that results in an excitation of the lanthanide compound(s).
A method for producing polymer particles, comprising one or more water soluble lanthanide compounds having a photon energy >38 keV and a K absorption edge Z >56 that are embedded in a solid biodegradable polymer particle, the polymer being selected from the group consisting of polycarbonic acids, polylactic acids, polyglycolic acids, polypeptides or combinations thereof by incubating the polymer with the lanthanide compound in a suitable solvent solution, emulsifying the polymer/lanthanide mixture and applying solvent evaporation to hardening the particles.
A pharmaceutical composition, comprising one or more water soluble lanthanide compounds having a photon energy >38 keV and a K absorption edge Z >56 that are embedded in a solid biodegradable polymer particle, the polymer being selected from the group consisting of polycarbonic acids, polylactic acids, polyglycolic acids, polypeptides or combinations thereof for use in the treatment of a pathological disease.
Dependencies are inferred from the claim text.