Back to results
US 2014/0350095 A1Published application
3' Equatorial-Fluorine-Substituted Neuraminidase Inhibitor Compounds, Compositions and Methods for the Use Thereof as Anti-Virals
AssigneeThe University of British Columbia
InventorsStephen Withers, Hongming Chen, Ricardo Resende, Jennifer Lois Breschkin
Life of this patent
Estimating the term…
Abstract
Equatorial 2,3-fluorinated glycosides compounds of formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza, the methods for their preparation, and their pharmaceutical compositions. The therapeutic effect is achieved via inhibition of viral neuraminidases.
Claims19
A compound of formula I:
- wherein
- T is COOH or COOR1,
- wherein R1 is a C1-20 linear, branched or cyclic, saturated or unsaturated, unsubstituted alkyl group,
- Z is F, or Cl;
- D is F, or Cl;
- X is NH2, NHC(NH)NH2, NHCH3, NHCH2CH3, NHCH2CH2CH3, NHCH2CH2CH2CH3, or NHC(CH3)CH3;
- Q is OH, OMe, or OAc;
- E is OH, or OAc;
- and
- A is OH, or OAc.
7 more elements
A compound having the formula:
A compound having the formula:
Dependencies are inferred from the claim text.