Pharmaceutical Compositions Comprising Imatinib and a Release Retardant
AssigneeNovartis AG
InventorsMadhav Vasanthavada, Jay Parthiban, Wei-Qin Tong, Abu T. M. Serajuddin
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Abstract
Sustained release pharmaceutical compositions that contain imatinib or a pharmaceutically acceptable salt thereof. The pharmaceutical compositions further contain a release retardant, for example a water soluble, a water swellable and/or a water insoluble polymer. The present invention also features a particularly useful process of making such sustained release pharmaceutical compositions by using an extruder.
Claims26
1-25. (canceled)
A pharmaceutical composition comprising imatinib or any of its salts and a release retardant.
A method of making a modified release pharmaceutical composition comprising the step of granulating imatinib or any of its salts with a release retardant and optionally a release modifier in an extruder while heating to a temperature below the melting temperature of imatinib or its salt, to form melt granules.
Dependencies are inferred from the claim text.