A compound for the treatment of obesity, hypercholesterolemia, hyperlipidemia, dyslipidemia, mixed dyslipidemia, hypertriglyceridemia, fatty liver, nonalcoholic fatty liver disease, liverfibrosis, non-alcoholic steatohepatitis and diabetes, wherein the compound has the following formula
- including any stereochemically isomeric form thereof, wherein
- A represents CH;
- the dotted line represents an optional bond in case A represents a carbon atom;
- X represents —NRx—C(═O)—;
- —Z—C(═O)—;
- —Z—NRx—C(═O)—;
- —S(═O)p-;
- —C(═S)—;
- —NRx—C(═S)—;
- —Z—C(═S)—;
- —Z—NRx—C(═S)—;
- —O—C(═O)—;
- or —C(═O)—C(═O)—;
- Z represents a bivalent radical selected from C1-6alkanediyl, C2-6alkenediyl or C2-6alkynediyl;
- wherein each of said C1-6alkanediyl, C2-6alkenediyl or C2-6alkynediyl may optionally be substituted with hydroxyl or amino;
- and wherein two hydrogen atoms attached to the same carbon atom in C1-6alkanediyl may optionally be replaced by C1-6alkanediyl;
- Rx represents hydrogen or C1-4alkyl;
- R1 represents a 5-membered monocyclic heterocycle containing at least 2 heteroatoms;
- a 6-membered aromatic monocyclic heterocycle;
- or a 5-membered heterocycle containing at least 2 heteroatoms fused with phenyl, cyclohexyl or a 5- or 6-membered heterocycle;
- wherein each of said heterocycles may optionally be substituted with at least one substituent, each substituent independently being selected from the group consisting of hydroxyl;
- oxo;
- carboxyl;
- halo;
- C1-6alkyl optionally substituted with carboxyl, C1-4alkyloxycarbonyl or aryl-C(═O)—;
- hydroxyC1-6alkyl optionally substituted with aryl or aryl-C(═O)—;
- polyhaloC1-6alkyl;
- C1-6alkyloxy optionally substituted with C1-4alkyloxy;
- C1-6alkylthio;
- polyhaloC1-6alkyloxy;
- C1-6alkyloxy-carbonyl wherein C1-6alkyl may optionally be substituted with aryl;
- cyano;
- aminocarbonyl;
- mono- or di(C1-4alkyl)-aminocarbonyl;
- C1-6alkylcarbonyl;
- amino;
- mono- or di(C1-6alkyl)amino;
- R5R4N—C1-6alkyl;
- C3-6cycloalkyl-NRx—;
- aryl-NRx—;
- Het-NRx—;
- C3-6cycloalkyl-C1-4alkyl-NRx—;
- arylC1-4alkyl-NRx—;
- HetC1-4alkyl-NRx—;
- —S(═O)p—C1-4alkyl;
- C3-6cycloalkyl;
- C3-6cycloalkylC1-4alkyl;
- C3-6cycloalkyl-C(═O)—;
- aryl;
- aryloxy;
- arylC1-4alkyl;
- aryl-C(═O)—;
- aryl-C(═O)—C1-4alkyl;
- Het;
- HetC1-4alkyl;
- Het-C(═O)—;
- Het-C(═O)—C1-4alkyl;
- and Het-O—;
- R2 represents R3;
- R3 represents C3-6cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms, wherein said C3-6cycloalkyl, phenyl, naphtalenyl,
- 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or 6-membered aromatic heterocycle may optionally be substituted with at least one substituent, each substituent independently selected from the group consisting of hydroxyl;
- carboxyl;
- halo;
- C1-6alkyl optionally substituted with hydroxy;
- polyhaloC1-6alkyl;
- C1-6alkyloxy optionally substituted with C1-4alkyloxy;
- C1-6alkylthio;
- polyhalo-C1-6alkyloxy;
- C1-6alkyloxycarbonyl wherein C1-6alkyl may optionally be substituted with aryl;
- cyano;
- C1-6alkylcarbonyl;
- nitro;
- amino;
- mono- or di(C1-4alkyl)amino;
- C1-4alkylcarbonylamino;
- —S(═O)p—C1-4alkyl;
- R5R4N—C(═O)—;
- R5R4N—C1-6alkyl;
- C3-6cycloalkyl;
- C3-6cycloalkyl-C1-4alkyl;
- C3-6cycloalkyl-C(═O)—;
- aryl;
- aryloxy;
- arylC1-4alkyl;
- aryl-C(═O)—C1-4alkyl;
- aryl-C(═O)—;
- Het;
- HetC1-4alkyl;
- Het-C(═O)—C1-4alkyl;
- Het-C(═O)—;
- and Het-O—;
- R4 represents hydrogen;
- C1-4alkyl optionally substituted with hydroxyl or C1-4alkyloxy;
- R7R6N—C1-4alkyl;
- C1-4alkyloxy;
- Het;
- aryl;
- or R7R6N—C(═O)—C1-4alkyl;
- R5 represents hydrogen or C1-4alkyl;
- R6 represents hydrogen;
- C1-4alkyl;
- or C1-4alkylcarbonyl;
- R7 represents hydrogen or C1-4alkyl;
- or
- R6 and R7 may be taken together with the nitrogen to which they are attached to form a saturated monocyclic 5, 6 or 7-membered heterocycle which may further contain one or more heteroatoms selected from the group consisting of O, S, S(═O)p and N;
- and which heterocycle may optionally be substituted with C1-4alkyl;
- R8 represents hydrogen;
- halo;
- C1-4alkyl;
- or C1-4alkyl substituted with hydroxyl;
- aryl represents phenyl or phenyl substituted with at least one substituent, each substituent independently being selected from the group consisting of hydroxyl;
- carboxyl;
- halo;
- C1-6alkyl optionally substituted with
- C1-4alkyloxy, amino or mono- or di(C1-4alkyl)amino;
- polyhaloC1-6alkyl;
- C1-6alkyloxy optionally substituted with C1-4alkyloxy;
- C1-6alkylthio;
- polyhaloC1-6alkyloxy;
- C1-6alkyloxycarbonyl;
- cyano;
- aminocarbonyl;
- mono- or di(C1-4alkyl)aminocarbonyl;
- C1-6alkylcarbonyl;
- nitro;
- amino;
- mono- or di(C1-4alkyl)amino;
- and —S(═O)p—C1-4alkyl;
- Het represents a monocyclic non-aromatic or aromatic heterocycle containing at least one heteroatom selected from the group consisting of O, S, S(═O)p and N;
- or a bicyclic or tricyclic non-aromatic or aromatic heterocycle containing at least one heteroatom selected from the group consisting of O, S, S(═O)p and N;
- said monocyclic heterocycle or said bi- or tricyclic heterocycle optionally being substituted with at least one substituent, each substituent independently being selected from the group consisting of hydroxyl;
- oxo;
- carboxyl;
- halo;
- C1-6alkyl optionally substituted with C1-4alkyloxy, amino or mono- or di(C1-4alkyl)amino;
- polyhaloC1-6alkyl;
- C1-6alkyloxy optionally substituted with C1-4alkyloxy;
- C1-6alkylthio;
- polyhaloC1-6alkyloxy;
- C1-6alkyl-oxycarbonyl;
- cyano;
- aminocarbonyl;
- mono- or di(C1-4alkyl)aminocarbonyl;
- C1-6alkylcarbonyl;
- nitro;
- amino;
- mono- or di(C1-4alkyl)amino;
- and —S(═O)p—C1-4alkyl
- p represents 1 or 2;
- a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof.