Imidazo[4,5-b]pyridine Derivatives as ALK and JAK Modulators for the Treatment of Proliferative Disorders

A compound of the general formula (I):

• or a salt thereof, wherein:
• W is H and Z is selected from
• or
• W and Z are taken together to form
• R1 is selected from (C6-C10)aryl, aminophenyl, (C2-C9)heterocycloalkyl, (C1-C9)heteroaryl or a group of formula
• wherein any of the foregoing may be optionally substituted with one or more R6 groups;
• R2 is selected from hydrogen or halogen;
• R3 is selected from CH2OH or CONR4R5;
• Q is selected from CH2 or O;
• “------” is either present so as to form a double bond or is absent;
• R4 and R5 are each independently selected from H, (C1-C6)alkyl, (C3-C8)cycloalkyl, (C1-C6)alkyl(C3-C8)cycloalkyl, or (C1-C6)alkyl-OR9 wherein any of the foregoing except for H may be optionally substituted with one or more R7;
• Each R6 is independently selected from (C0-C4)alkylCO2R8, (C0-C4)alkylCON(O2, (C0-C4)alkylCOR8, (C0-C4)alkylN(R8)2, (C0-C4)OR9, (C1-C6)alkoxy, (C1-C6)alkoxy(C2-C9)heterocycloalkyl, (C1-C6)alkoxy(C3-C8)cycloalkyl, (C1-C6)alkyl, (C1-C6)alkyl(C1-C9)heteroaryl, (C1-C6)alkyl(C2-C9)heterocycloalkyl, (C1-C6)alkyl(C3-C8)cycloalkyl, (C1-C6)alkyl(C6-C10)aryl, (C1-C9)heteroaryl, (C2-C6)alkenyl, (C2-C9)heterocycloalkyl, (C2-C9)heterocycloalkyloxy, (C3-C8)cycloalkyl, (C3-C8)cycloalkyloxy, (C3-C9)heterocycloalkenyl, (C6-C10)aryl, cyano, halo(C1-C6)alkoxy, halo(C1-C6)alkyl, halogen, O(C0-C4)alkylCO2R8, O(C0-C4)alkylCON(R8)2, O(C0-C4)alkylCOR8, PO((C1-C4)alkyl)2, or O(C0-C4)alkylN(R8)2, wherein any of the foregoing except for halogen, may be optionally substituted with one or more R7;
• Each R7 is independently selected from (C0-C4)alkylCO2R8, (C0-C4)alkylCON(R8)2, (C0-C4)alkylCOR8, (C0-C4)OR9, (C1-C6)alkoxy, (C1-C6)alkyl, (C1-C6)alkyl(C1-C9)heteroaryl, (C1-C6)alkyl(C2-C9)heterocycloalkyl, (C1-C6)alkyl(C3-C8)cycloalkyl, (C1-C6)alkyl(C6-C10)aryl, (C1-C9)heteroaryl, (C2-C9)heterocycloalkyl, (C2-C9)heterocycloalkyl optionally substituted with (C1-C6)alkyl, (C3-C8)cycloalkyl, (C6-C10)aryl, halo(C1-C6)alkoxy, halo(C1-C6)alkyl, halogen, hydroxy(C1-C6)alkyl, PO((C1-C4)alkyl)2, or hydroxy(C1-C6)alkyl(C1-C6)alkoxy;
• Each R8 is independently selected from H, (C1-C6)alkyl, (C2-C9)heterocycloalkyl, or two R8 are taken together with the nitrogen atom to which they are attached to form (C2-C9)heterocycloalkyl, wherein any of the foregoing except for H, may be optionally substituted with (C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, halogen, (C0-C4)alkylCO2R9, (C0-C4)alkylN(R9)2 or (C0-C4)alkylOR9;
• R9 is independently selected from H or (C1-C6)alkyl;
• and
• R10 is independently a carbonyl or a hydroxyl group.