Targeted antimicrobial moieties
AssigneeC3 Jian, Inc.
InventorsRANDAL H. ECKERT, CHRIS KAPLAN, JIAN HE, DANIEL K. YARBROUGH, MAXWELL ANDERSON, JEE-HYUN SIM
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Abstract
This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
Claims32
A chimeric construct, said construct comprising:
- an effector attached to a peptide targeting moiety comprising an amino acid sequence found in Table 3 and/or Table 12.
2-5. (canceled)
8-12. (canceled)
21-26. (canceled)
28-29. (canceled)
An antimicrobial composition effective to kill or to inhibit the growth and/or of a microorganism and/or the formation and/or maintenance of a biofilm, said composition comprising one or more isolated antimicrobial peptides, the amino acid sequences of said peptides comprising one or more sequences selected from the amino acid sequences listed in Table 4 and/or Table 5.
31-55. (canceled)
(canceled)
61-65. (canceled)
67-80. (canceled)
A method of detecting a bacterium and/or a bacterial film, said method comprising:
- contacting said bacterium or bacterial film with a composition comprising a detectable label attached to a targeting peptide comprising one or more amino acid sequences found Table 3 and/or Table 12;
- and
- detecting said detectable label wherein the quantity and/or location of said detectable label is an indicator of the presence of said bacterium and/or bacterial film.
82-83. (canceled)
A composition comprising a photosensitizing agent attached to a targeting peptide comprising an amino acid sequence of a peptide found in Table 3 and/or Table 12.
85-90. (canceled)
92-112. (canceled)
Dependencies are inferred from the claim text.