Data analysis methods utilizing phenotypic properties
OwnerRobert Balderas, Mirko Corselliinventors
Life of this patent
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Abstract
The present invention provides a method of identifying sub-populations of cells in a cellular sample. Aspects of the method include categorizing cells of the cellular sample into at least a first and second population based on a first phenotypic property. The method may further include sub-categorizing each of the first and second population into sub-populations of cells based on a second and third phenotypic property, e.g., by using X detectable labels providing Y distinct signals, wherein X>Y, to identify sub-populations of cells in the cellular sample.
Claims24
A method of identifying sub-populations of cells in a cellular sample, the method comprising:
- categorizing cells of the cellular sample into at least a first and second population based on a first phenotypic property;
- and
- sub-categorizing each of the first and second populations into sub-populations of cells based on a second and third phenotypic property using X detectable labels providing Y distinct signals, wherein X>Y, to identify sub-populations of cells in the cellular sample.
(canceled)
16-25. (canceled)
A labeled cellular sample, the sample comprising:
- cells,
- a first detectable label that specifically binds to a first cellular marker;
- and
- a second detectable label that specifically binds to a second cellular marker;
- wherein the first and second detectable labels provide a substantially identical signal.
27-39. (canceled)
A flow cytometry system comprising:
- a flow cytometer configured to produce a data set;
- a data processing unit;
- and
- a memory storing a module for execution by the data processing unit, wherein the module is configured to transform the data set from a number (X) of signal sets to a number (Y) of marker density sets, wherein Y>X.
41-60. (canceled)
A module for execution by a data processing unit of a flow cytometry system, the module configured to transform the data set from a number (X) of signal sets to a number (Y) of marker density sets, wherein Y>X.
62-67. (canceled)
A kit comprising:
- a first detectable label that specifically binds to a first cellular marker;
- and
- a second detectable label that specifically binds to a second cellular marker;
- wherein the first and second detectable labels provide a substantially identical signal.
69-75. (canceled)
Dependencies are inferred from the claim text.