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AssigneesMassachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation
InventorsJeffrey M. Karp, Pedro del Nido, Nora Lang, Robert S. Langer, Maria Jose M.N. Pereira, Yuhan Lee
Estimating the term…
Pre-polymers for use as tissue sealants and adhesives, and methods of making and using thereof are provided. The pre-polymers have flow characteristics such that they can be applied through a syringe or catheter but are sufficiently viscous to remain in place at the site of application and not run off the tissue. The pre-polymers are also sufficiently hydrophobic to resist washout by bodily fluids. The pre-polymers are stable in bodily fluids; that is the pre-polymer does not spontaneously crosslink in bodily fluids absent the presence of an intentionally applied stimulus to initiate crosslinking. Upon crosslinking, the adhesive exhibits significant adhesive strength in the presence of blood and other bodily fluids. The adhesive is sufficiently elastic that it is able to resist movement of the underlying tissue. The adhesive can provide a hemostatic seal. The adhesive is biodegradable and biocompatible, causing minimal inflammatory response.
A hydrophobic viscous pre-polymer comprising a plurality of activated polymeric backbones, wherein the percent of activated functional groups on the polymeric backbone is greater than 1%, preferably 5%, more preferably 10%, more preferably 25%, most preferably 40%, wherein crosslinking of the pre-polymer is not initiated by bodily fluids.
Dependencies are inferred from the claim text.