Engineered Protein Coating for Medical Implants

Abstract

Engineered protein coatings are provided for medical implants to promote bone regeneration. The coating is an engineered protein containing an elastin-like structural domain (SEQ ID No: 2) and a cell-adhesive domain derived from an extended fibronectin RGD sequence. The surface of the medical implant is covalently and directly bonded to the coating via photoreactive crosslinking through an insertion and/or addition reaction. The engineered protein coating can be applied directly upon fabrication of the implant, which would eliminate applying the coating in the operating room. The engineered protein coating is also customizable and can include biologics to improve performance. Furthermore, the engineered protein coating could also be spatially patterned on the implant surface.

Dependencies are inferred from the claim text.