Method to modulate pigmentation process in the melanocytes of skin
AssigneeCouncil of Scientific and Industrial Research
InventorsRajesh Sudhir Gokhale, Vivek Tirunelveli Natarajan, Parul Ganju
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Abstract
The invention describes a method to modulate melanosome maturation process in melanocytes. Further, it describes a method to reversibly alter the process of pigmentation in the human epidermal skin. The method targets melanosome maturation and its transfer to keratinocytes, which are key processes involved in the pigmentation for its potential use in predictable and controlled regulation of pigmentation in human skin.
Claims9
A method to reversibly alter melanosome maturation occurring in stage I and II in an epidermal melanocytes in a subject by contacting or withdrawing IFN-γ and its derivative, mimic, antagonist thereof with said melanocytes in a controlled manner,
- and wherein the IFN-γ and derivative, mimic, antagonist thereof modulate the expression of IFN-γ pathway components selected from a group comprising IFNGR1, JAK1 and STAT1.
Use of IFN-γ and its components and its agonists and antagonists in modulating pigmentation in humans for clinical or cosmaceutical purposes.
A method of treating skin pigmentation by administering to a subject IFN-γ or its derivative, or a mimic or antagonist of IFN-γ.
Dependencies are inferred from the claim text.