Method and device for correcting optical signals

An optical detection device for monitoring an implant embedded in tissue of a mammalian body, the implant being capable of emitting, in response to excitation light within an excitation wavelength range, at least one analyte-dependent optical signal within an emission wavelength range, the device comprising:

• a) a first light source arranged to transmit first excitation light within the excitation wavelength range through the tissue to the implant;
• b) a second light source arranged to transmit second excitation light into the tissue, wherein the second excitation light is substantially within the emission wavelength range;
• and
• c) at least one detector arranged to measure, in response to the first excitation light, a first optical signal emitted from the tissue in the emission wavelength range and arranged to measure, in response to the second excitation light, a second optical signal emitted from the tissue in the emission wavelength range.

A method for correcting at least one analyte-dependent optical signal emitted from an implant embedded in tissue of a mammalian body, the implant being capable of emitting, in response to excitation light within an excitation wavelength range, the analyte-dependent optical signal within an emission wavelength range, the method comprising:

• a) transmitting first excitation light within the excitation wavelength range through the tissue to the implant;
• b) measuring, in response to the first excitation light, a first optical signal emitted from the tissue within the emission wavelength range;
• c) transmitting second excitation light within the excitation wavelength range into the tissue;
• d) measuring, in response to the second excitation light, a second optical signal emitted from the tissue within the emission wavelength range, wherein the second excitation light and light emitted in response to the second excitation light form a light path that is spaced laterally from the implant a sufficient distance to avoid significant contribution from implant reporters;
• and
• e) determining at least one corrected signal value in dependence upon the measured optical signals.

An optical detection device for monitoring an implant embedded in tissue of a mammalian body, the implant being capable of emitting, in response to excitation light within an excitation wavelength range, at least one analyte-dependent optical signal within an emission wavelength range, the device comprising:

• a) a first light source arranged to transmit first excitation light in the excitation wavelength range through the tissue to the implant;
• b) a first detector arranged to measure, in response to the first excitation light, a first optical signal emitted from the tissue in the emission wavelength range;
• c) a second light source arranged to transmit second excitation light in the excitation wavelength range into the tissue;
• and
• d) a second detector arranged to measure, in response to the second excitation light, a second optical signal emitted from the tissue within the emission wavelength range, wherein the second light source and the second detector are positioned with respect to each other such that the second excitation light and the light emitted in response to the second excitation light form a light path that is spaced laterally from the implant a sufficient distance to avoid significant contribution from implant reporters.