Pathological state detection using dynamically determined body index range values

A method of determining a pathological state in a patient, comprising:

• receiving data relating to an activity level of said patient;
• determining an activity level of the patient based on said data relating to an activity level;
• receiving at least one body signal of the patient;
• determining at least a first body index based on said at least one body signal;
• dynamically determining a reference value range for said at least a first body index based on said activity level;
• determining that the patient is in one of a non-pathological state and a pathological state, wherein said patient is determined to be in a non-pathological state if the at least a first body index is within said reference value range for said activity level, and said patient is determined to be in a pathological state if the at least a first body index is outside said reference value range;
• and
• taking at least one further action based on determining that the patient is in a pathological state, wherein said further action is selected from treating said pathological state, issuing a warning to the patient or a caregiver regarding said pathological state, logging the occurrence of said pathological state, logging the response to a therapy, or logging a severity of said pathological state.

A medical device system, comprising:

• at least one kinetic sensor, each said sensor configured to collect at least one kinetic signal from a patient;
• an activity level module configured to determine an activity level of said patient, based at least in part on said at least one kinetic signal;
• at least one sensor configured to sense a body signal;
• a body index determination module configured to determine at least a first body index based on said sensed body signal;
• a body index range module, configured to determine a non-pathological body index range for said at least a first body index, based at least in part on said activity level;
• and
• a pathological state determination module, configured to determine that the patient is in one of a non-pathological state and a pathological state, wherein said patient is determined to be in a non-pathological state if the at least a first body index is within said non-pathological body index range for said at least a first body index, and said patient is determined to be in a pathological state if the at least a first body index is outside said non-pathological body index range for said at least a first body index.