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US 2014/0275547 A1Published application
Stable sns-595 compositions and methods of preparation
AssigneeSunesis Pharmaceuticals, Inc.
InventorsAnantha Sudhakar, Jeff Jacobs, Ahmad Hashash, Sean Ritchie, Henggin Cheng
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Abstract
Methods of preparing substantially pure SNS-595 substance are disclosed. Also provided are compositions comprising SNS-595 substance that are substantially pure and essentially free of visible particles.
Claims16
A process for preparing a substantially pure SNS-595 substance, comprising:
- (a) reacting Compound 3
- with a first aqueous base followed by neutralizing to obtain a primary SNS-595 hydrate;
- (b) dehydrating the primary SNS-595 hydrate from step (a) and reacting the dehydrated product with a second aqueous base followed by neutralizing to obtain a secondary SNS-595 hydrate;
- and
- (c) dehydrating the secondary SNS-595 hydrate obtained in step (b) to obtain the substantially pure SNS-595 substance.
2 more elements
A process for preparing substantially pure Compound 3
- comprising reacting Compound 1
- with Compound 2
- in the presence of N,N-diisopropylethylamine and water to obtain substantially pure Compound 3.
A process for preparing a substantially pure SNS-595 substance, comprising:
- (a) reacting Compound 1
- with Compound 2
- in the presence of N,N-diisopropylethylamine and water to obtain substantially pure Compound 3
- (b) reacting the substantially pure Compound 3 with an aqueous base followed by neutralizing to obtain a primary SNS-595 hydrate;
- and
- (c) dehydrating the primary SNS-595 hydrate obtained in step (a) to obtain the substantially pure SNS-595 substance.
3 more elements
11-32. (canceled)
Dependencies are inferred from the claim text.