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US 2014/0275511 A1Published application
Purification of nikkomycin z
OwnerDavid J. Larwoodinventor
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Abstract
This invention relates to an improved method of purifying Nikkomycin Z, an antifungal compound shown to be particularly useful in treating Valley Fever, coccidioidomycosis. The improvement of this invention lies in the choice of resins and elution conditions, chosen to minimize handling of the material.
Claims1
A process for concentrating Nikkomycins Z from a dilute impure aqueous solution thereof containing Nikkomycin Z comprising
- bringing the solution to a pH between about 4 and 7,
- contacting the solution with a suitable cation exchange resin,
- eluting the adsorbed material with a mild base solution,
- transferring eluate of interest and contacting with a suitable anion exchange resin,
- eluting the adsorbed material with a mild acid solution,
- transferring eluate of interest to a HIC column,
- eluting the material with water,
- thereby to obtain a concentrated and purified solution of Nikkomycin Z.
5 more elements
Dependencies are inferred from the claim text.