Back to results
US 2014/0275508 A1Published application
Artificial nucleic acids
AssigneeElitech Holding B.V.
InventorsNoah Scarr, Eugeny A. Lukhtanov
Life of this patent
Estimating the term…
Abstract
Artificial nucleosides including 2-methyl-nucleobase-substituted butane-1,3-diol nucleosides are disclosed. Four different stereoisomers of such nucleosides are possible. Oligonucleotides made up of the artificial nucleosides form homoduplexes of greater stability than DNA duplexes and have a reduced ability to hybridize to DNA or RNA.
Claims5
Nucleoside analogues of Formulas I and II:
- wherein B is a natural or artificial nucleic acid base;
- X is —CH2— or substituted carbon;
- and
- n is 1 or 2.
1 more element
Dependencies are inferred from the claim text.