Methods for the selective sequestration of alkyne-presenting molecules and related compositions and methods

A method for selectively sequestering one or more alkyne-presenting molecules from an unprepared matrix, the method comprising:

• contacting a sequestration reagent with the unprepared matrix for a time and under a condition to allow binding of the sequestration reagent the one or more alkyne-presenting molecules possibly present in the matrix to the sequestration reagent thus sequestering the alkyne-presenting molecules from the unprepared matrix;
• wherein the sequestration reagent comprises a support presenting one or more azide groups, wherein binding of the azide group to the one or more alkyne-presenting molecules results in sequestration of the alkyne-presenting molecules from the matrix.