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US 2014/0275234 A1Published application
Compositions and methods of using crystalline forms of wortmannin analogs
AssigneeOncothyreon Inc.
InventorsJeffrey Millard, Gary Christianson, Eric Charles
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Abstract
Provided herein are novel crystalline forms of Compound 1. Also provided herein are compositions and methods of uses for the crystalline forms of Compound 1.
Claims34
A crystalline form of a compound having a structural formula
- which is substantially free of wortmannin.
A crystalline form of a compound having a structural formula
- wherein the form is
- (a) a crystalline anisole solvate;
- and
- (b) has an X-ray powder diffraction pattern (XRPD) with characteristic peaks at 7.9±0.1 degrees 2-Theta, 8.5±0.1 degrees 2-Theta, 10.2±0.1 degrees 2-Theta, 11.1±0.1 degrees 2-Theta, 14.0±0.1 degrees 2-Theta, 14.2±0.1 degrees 2-Theta, 17.9±0.1 degrees 2-Theta, 18.7±0.1 degrees 2-Theta, 21.0±0.1 degrees 2-Theta, 21.2±0.1 degrees 2-Theta, and 28.2±0.1 degrees 2-Theta.
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A method of preparing a crystalline solvate form of a compound having a structural formula
- that is substantially free of wortmannin, comprising cooling down a supernatant, solution, suspension, dispersion or emulsion of the compound in a suitable solvent to a temperature of between 4° C. to −20° C.
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The method of 30, wherein the method further comprises administering an anti-cancer agent.
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Dependencies are inferred from the claim text.