Method of dosing and use of soft anticholinergic esters
AssigneeBodor Laboratories, Inc.
InventorsNICHOLAS S. BODOR, DAVID ANGULO
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Abstract
A method of treating hyperhidrosis in a mammalian subject comprising: a) providing a composition comprising a pharmaceutically acceptable vehicle and from about 1.0% to about 25% of a compound having the formula: and b) topically administering the composition to skin of an area of a mammalian subject suffering from hyperhidosis, before bedtime, such that, compared to untreated, baseline conditions, sweat production is reduced by at least about 25% for at least about six (6) hours.
Claims16
A method of treating hyperhidrosis in a mammalian subject comprising:
- a) providing a composition comprising a pharmaceutically acceptable vehicle and from about 1.0% to about 25% of a compound having the formula:
- wherein R is methyl or ethyl, said compound having the R stereoisomeric configuration at the 2 position and the R, S, or RS steroisomeric configuration at the 1′ and 3′ position, or being a mixture thereof;
- and
- b) topically administering the composition to skin of an area of a mammalian subject suffering from hyperhidosis, before bedtime, such that, compared to untreated, baseline conditions, sweat production is reduced by at least about 25% for at least about six (6) hours.
A method of dosing a subject suffering from hyperhidrosis, said method of dosing comprising the steps of:
- a) providing a composition comprising a pharmaceutically acceptable vehicle and from about 1.0% to about 25% of a compound having the formula:
- wherein R is methyl or ethyl, said compound having the R stereoisomeric configuration at the 2 position and the R, S, or RS steroisomeric configuration at the 1′ and 3′ position, or being a mixture thereof;
- and
- b) administering before bedtime the composition to skin of an area of a subject suffering from hyperhidrosis such that, compared to untreated, baseline conditions, sweat production is reduced by at least about 25% for at least about six (6) hours.
Dependencies are inferred from the claim text.