US 2014/0275203 A1 · Method for Inhibiting Differentiation of Osteoclast and Pharmaceutical Composition Comprising Thereof

Abstract

The present invention is for method of treating metabolic bone disease, new compounds and pharmaceutical compositions comprising the active ingredients having inhibition effects on osteoclast differentiation. The pharmaceutical composition comprising new compounds according to the present invention can be used as medicines for treating metabolic bone diseases such as bone metastatic cancer, solid cancer bone metastasis, musculoskeletal complication by solid cancer bone metastasis, hypercalcemia by malignant tumor, multiple myeloma, primary bone tumor, osteoporosis, rheumatoid arthritis, osteoarthritis, periodontal disease, inflammatory resorption of alveolar bone, inflammatory resorption of bone, and Paget's disease.

Claims7

Dependent claims

A method of treating metabolic bone disease comprising:

single or multiple administration of pharmaceutical composition comprising a compound of the following formula I, or pharmaceutically acceptable salts thereof as an active ingredient to a patient in need thereof,
wherein in Formula I, R1 represents phenyl, C6-10aryl, C6-10arylC1-6alkyl, C3-10cycloalkyl or 5-10 membered heteroaryl including at least one selected from nitrogen atom, oxygen atom and sulfur atom in a ring;
R2 and R3 each independently represent halogen, phenyl, hydroxy, C6-10aryl, C6-10arylC1-6alkyl, C3-10cycloalkyl or 5-10 membered heteroaryl including at least one selected from nitrogen atom, oxygen atom and sulfur atom in a ring;
and
X and Y each independently represent hydrogen, oxo, hydroxy, S or CH2.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/293,879Filed 2 Jun 2014

Priority

KR 10-2012-008224827 Jul 2012

Published

18 Sep 2014

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C07D 207/448
Having two doubly-bound oxygen atoms directly attached in positions 2 and 5: with only hydrogen atoms or radicals containing only hydrogen and…
A61K 31/4015
Having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil: having oxo groups…
A61P 19/00
Drugs for skeletal disorders
A61P 35/00
Antineoplastic agents

Method for Inhibiting Differentiation of Osteoclast and Pharmaceutical Composition Comprising Thereof

Life of this patent

Method for Inhibiting Differentiation of Osteoclast and Pharmaceutical Composition Comprising Thereof

Life of this patent

Abstract

Claims7