Use of analgesic potentiating compounds to potentiate the analgesic properties of an analgesic compound

A method for enhancing an analgesic response in a human desiring treatment for reducing acute pain which comprises orally administering to said human having acute pain a single dose composition comprising (i) an analgesic effective amount of a compound selected from the group consisting of naproxen and the pharmaceutically acceptable salt thereof at a dosage from 100 mg to 900 mg per single dose composition, and (ii) an analgesic potentiating amount of a compound selected from the group consisting of nizatidine and the pharmaceutically effective salt or isomer thereof at a dosage from 10 mg to 200 mg per single dose composition,

• wherein said single dose composition comprises an admixture of (i) and (ii), wherein the single dose composition does not have an enteric coating so that (i) and (ii) are released concomitantly after administration to said human,
• wherein said naproxen or the pharmaceutically acceptable salt thereof and said nizatidine or the pharmaceutically acceptable salt or isomer thereof provides an enhanced analgesic response in said human compared to the administration to said human of the same dosage strength of said naproxen or the pharmaceutically acceptable salt thereof in the absence of said nizatidine or the pharmaceutically acceptable salt or isomer thereof.