Macrocyclic picolinamides as fungicides

A composition for treating plants, comprising a compound of Formula I:

• wherein, R is H or C(O)R6;
• R1 is C(O)R6, or Q;
• Q is
• R2 is independently H, alkyl, alkenyl, aryl, heterocyclyl, each substituted with 0, 1 or multiple R5, or —C(O)R5;
• R3 is independently H, alkyl, or alkenyl, each substituted with 0, 1 or multiple R5;
• R4 is independently alkyl or alkoxy, substituted with 0, 1, or multiple R5;
• R5 is alkyl, alkenyl, halo, haloalkyl, alkoxy, haloalkoxy, C(O)R8, arylalkoxy, or aryl;
• R6 is alkoxy or benzyloxy;
• R7 is H, —C(O)R4, or —CH2OC(O)R4;
• and
• R8 is H, alkenyl, halo, haloalkyl, alkoxy, haloalkoxy, arylalkoxy, or aryl;
• and
• at least one of the following additional compounds selected from the group consisting of:
• phytologically acceptable carrier materials, pesticides, fungicides, insecticides, nematocides, miticides, arthropodicides, and bactericides.

A method for treating a plant, comprising the steps of:

• applying a agriculturally effective amount of at least one of the compounds of Formula I:
• wherein, R is H or C(O)R6;
• R1 is H, C(O)R6, or Q;
• Q is
• R2 is independently H, alkyl, alkenyl, aryl, heterocyclyl, each substituted with 0, 1 or multiple R5, or —C(O)R5;
• R3 is independently H, alkyl, or alkenyl, each substituted with 0, 1 or multiple R5;
• R4 is independently alkyl or alkoxy, substituted with 0, 1, or multiple R5;
• R5 is alkyl, alkenyl, halo, haloalkyl, alkoxy, haloalkoxy, C(O)R8, arylalkoxy, or aryl;
• R6 is alkoxy or benzyloxy;
• R7 is H, —C(O)R4, or —CH2OC(O)R4;
• and
• R8 is H, alkenyl, halo, haloalkyl, alkoxy, haloalkoxy, arylalkoxy, or aryl, to at least a portion of a plant, an area adjacent to a plant, and/or soil adapted to support growth of a plant.

A compound of Formula I:

• wherein, R is H;
• R1 is H;
• R2 is independently H, alkyl, alkenyl, aryl, heterocyclyl, each substituted with 0, 1 or multiple R5, or —C(O)R5;
• and
• R3 is independently H, alkyl, or alkenyl, each substituted with 0, 1 or multiple R5.