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US 2014/0275122 A1Published application
Voriconazole Formulations
AssigneeFresenius Kabi USA, LLC
InventorsBeena Uchil, Joel Hoekstra
Life of this patent
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Abstract
A voriconazole composition includes voriconazole, hydroxypropyl β-cyclodextrin, and an excipient selected from the group consisting of an amino acid and a disaccharide, where the composition is a solid. The solid composition may be made by forming a liquid mixture including a solvent, voriconazole, HPCD, and an excipient selected from the group consisting of an amino acid and a disaccharide, and lyophilizing the liquid mixture.
Claims20
A composition, comprising:
- voriconazole,
- hydroxypropyl β-cyclodextrin (HPCD), and
- an excipient selected from the group consisting of an amino acid and a disaccharide;
- where the composition is a solid.
1 more element
A composition, comprising:
- voriconazole,
- hydroxypropyl β-cyclodextrin (HPCD), and
- arginine;
- where the molar ratio of voriconazole to HPCD is from 1:2.7 to 1:3.5,
- the molar ratio of voriconazole to arginine is from 1:9 to 1:11, and
- the composition is a solid.
3 more elements
A composition, formed by a method comprising:
- forming a liquid mixture comprising
- a solvent,
- voriconazole,
- hydroxypropyl β-cyclodextrin (HPCD), and
- an excipient selected from the group consisting of an amino acid and a disaccharide;
- and
- lyophilizing the liquid mixture to form a solid composition.
4 more elements
Dependencies are inferred from the claim text.