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US 2014/0275096 A1Published application
P2x7 modulators
AssigneeJanssen Pharmaceutica NV
InventorsMichael K. Ameriks, Jason C. Rech, Brad M. Savall
Life of this patent
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Abstract
The present invention is directed to a compound of Formula (I) and to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
Claims23
A compound of Formula I wherein:
- R2 is H, halo, SO2CH3, C1-3 alkyl, NO2, NH2, perhaloalkyl or perhaloalkoxy;
- or two R2 substituents are taken together to form:
- n is 0-3;
- X is H or C1-C3 alkyl;
- Y is H, C1-C3 alkyl or C3-C4 cycloalkyl;
- R1 is selected from the group consisting of:
- Ra, Rc and Rg are independently H or halo;
- Rd is H or alkoxy;
- Re is H, C1-C3 alkyl or halo;
- Rb, Rf, Rh, Ri, Rj, Rk, Rl, Rm, Rn, Ro are independently H, C1-C3 alkyl or perhaloalkyl;
- Rp is H or C(O)OtBu;
- and
- pharmaceutically acceptable salts of compounds of Formula (I).
10 more elements
A compound selected from the group consisting of:
- 7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-(4-fluorophenyl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- 7-(2,3-Dichlorobenzyl)-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- 7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (±)7-{1-[2-Chloro-3-(trifluoromethyl)phenyl]ethyl}-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- 7-(2,6-Dichlorobenzyl)-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- 7-(2,3-Difluorobenzyl)-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- 7-[4-Chloro-2-(methylsulfonyl)benzyl]-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- 7-(2,3-Dichlorobenzyl)-3-pyridin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- 7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-pyridin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- 7-[2-Methyl-3-(trifluoromethyl)benzyl]-3-pyridin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (±)-7-(2,3-Dichlorobenzyl)-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6R)-7-(2,3-Dichlorobenzyl)-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-(2,3-Dichlorobenzyl)-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (±)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6R)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-(4-fluorophenyl)-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-pyridin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(5-methylpyrazin-2-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(1,3-oxazol-2-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(1,3-oxazol-4-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(1,3-oxazol-5-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(1-methyl-1H-pyrazol-3-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(1-methyl-1H-pyrazol-4-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(1H-pyrazol-4-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(5-methyl-1H-pyrazol-3-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-pyrimidin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(1H-pyrazol-3-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-pyridin-3-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-(5-fluoropyridin-2-yl)-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(1,3-thiazol-2-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(1,3-thiazol-4-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-pyrimidin-4-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-(5-fluoropyrimidin-2-yl)-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-(4-methoxypyridin-2-yl)-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(2-methyl-1,3-thiazol-4-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(1,3-thiazol-5-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-[2-(trifluoromethyl)-1,3-thiazol-4-yl]-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-(2,4-dimethyl-1,3-thiazol-5-yl)-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(4-methyl-1,3-thiazol-5-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-isoxazol-3-yl-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-3-(5-Bromopyrimidin-2-yl)-7-[2-chloro-3-(trifluoromethyl)benzyl]-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-3-(5-Tritiopyrimidin-2-yl)-7-[2-chloro-3-(trifluoromethyl)benzyl]-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-pyridazin-3-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-(5-fluoropyridin-3-yl)-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(6-methylpyridin-2-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-pyridin-4-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(2-methylpyridin-3-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-cyclobutyl-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-cyclopropyl-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-3-cyclohexyl-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-3-(5-Chloropyridin-3-yl)-7-[2-chloro-3-(trifluoromethyl)benzyl]-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-[4-(trifluoromethyl)pyrimidin-2-yl]-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-[6-(trifluoromethyl)pyridin-2-yl]-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-3-(5-Chloropyridin-2-yl)-7-[2-chloro-3-(trifluoromethyl)benzyl]-6-methyl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-(5-methylpyridin-3-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-tert-Butyl3-{7-[2-chloro-3-(trifluoromethyl)benzyl]-6-methyl-8-oxo-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}pyrrolidine-1-carboxylate;
- (6S)-tert-Butyl3-{7-[2-chloro-3-(trifluoromethyl)benzyl]-6-methyl-8-oxo-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}piperidine-1-carboxylate;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-methyl-3-piperidin-3-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (±)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-cyclopropyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6R*)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-cyclopropyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S*)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-cyclopropyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (±)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-cyclopropyl-3-pyrimidin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6R*)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-cyclopropyl-3-pyrimidin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S*)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-cyclopropyl-3-pyrimidin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (±)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-cyclopropyl-3-pyridin-3-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (±)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-cyclopropyl-3-(1H-pyrazol-3-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (±)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-cyclopropyl-3-(5-fluoropyridin-2-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (±)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-cyclopropyl-3-(5-fluoropyrimidin-2-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-ethyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-ethyl-3-pyrimidin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-ethyl-3-pyridin-3-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-ethyl-3-(1H-pyrazol-3-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-ethyl-3-(5-fluoropyrimidin-2-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-ethyl-3-(5-fluoropyridin-2-yl)-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-6-Methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-(2-Chloro-4-fluorobenzyl)-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-Benzyl-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-(2-Chlorobenzyl)-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[2-Chloro-4-(methylsulfonyl)benzyl]-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[4-Chloro-2-(methylsulfonyl)benzyl]-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-6-Methyl-3-pyrazin-2-yl-7-[2-(trifluoromethoxy)benzyl]-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-[(6-Chloro-1,3-benzodioxol-5-yl)methyl]-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-6-Methyl-7-[2-methyl-3-(trifluoromethyl)benzyl]-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-(2,6-Dichlorobenzyl)-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-(2,6-Dimethyl benzyl)-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-6-Methyl-3-pyrazin-2-yl-7-[3-(trifluoromethyl)benzyl]-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-6-Methyl-7-(2-nitrobenzyl)-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-(2-Chloro-5-nitrobenzyl)-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-7-(5-Amino-2-chlorobenzyl)-6-methyl-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-6-Methyl-7-(1-phenylethyl)-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-6-Methyl-7-[(1R/S)-1-phenylethyl]-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- (6S)-6-Methyl-7-[(1R*)-1-phenylethyl]-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;
- and
- (6S)-6-Methyl-7-[(1S*)-1-phenylethyl]-3-pyrazin-2-yl-6,7-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one.
93 more elements
A pharmaceutical composition for treating a disease, disorder or medical condition mediated by P2X7 activity comprising:
- (a) an effective amount of at least one compound selected from compounds of Formula (I) wherein:
- R2 is H, halo, SO2CH3, C1-3 alkyl, NO2, NH2, perhaloalkyl or perhaloalkoxy;
- or two R2 substituents are taken together to form:
- n is 0-3;
- X is H or C1-C3 alkyl;
- Y is H, C1-C3 alkyl or C3-C4 cycloalkyl;
- R1 is selected from the group consisting of:
- Ra, Rc and Rg are independently H or halo;
- Rd is H or alkoxy;
- Re is H, C1-C3 alkyl or halo;
- Rb, Rf, Rh, Ri, Rj, Rk, Rl, Rm, Rn, Ro are independently H, C1-C3 alkyl or perhaloalkyl;
- Rp is H or C(O)OtBu;
- and
- pharmaceutically acceptable salts of compounds of Formula (I);
- (b) at least one pharmaceutically acceptable excipient.
12 more elements
A method of treating a subject suffering from or diagnosed with a disease, disorder, or medical condition mediated by P2X7 receptor activity, comprising administering to a subject in need of such treatment an effective amount of at least one compound selected from compounds of Formula (I) wherein:
- R2 is H, halo, SO2CH3, C1-3 alkyl, NO2, NH2, perhaloalkyl or perhaloalkoxy;
- or two R2 substituents are taken together to form:
- n is 0-3;
- X is H or C1-C3 alkyl;
- Y is H, C1-C3 alkyl or C3-C4 cycloalkyl;
- R1 is selected from the group consisting of:
- Ra, Rc and Rg are independently H or halo;
- Rd is H or alkoxy;
- Re is H, C1-C3 alkyl or halo;
- Rb, Rf, Rh, Ri, Rj, Rk, Rl, Rm, Rn, Ro are independently H, C1-C3 alkyl or perhaloalkyl;
- Rp is H or C(O)OtBu;
- and
- pharmaceutically acceptable salts of compounds of Formula (I).
10 more elements
Dependencies are inferred from the claim text.