Azole derivative

An azole derivative represented by Formula (I):

• [in Formula (I),
• R1 represents a hydrogen atom, C1-5 alkyl (the C1-5 alkyl is optionally substituted by one to three groups selected from the group consisting of hydroxy, halogen atoms, cyano, C3-7 cycloalkyl, and C1-5 alkoxy), C3-7 cycloalkyl, or 4- to 8-membered saturated heterocycle;
• R2 represents a hydrogen atom or C1-5 alkyl;
• R3 represents aryl or heteroaryl (the aryl and heteroaryl are optionally substituted by one or two groups selected from the group consisting of C1-5 alkoxy, C1-5 alkyl, halogen atoms, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, difluoromethoxy, and C1-5 alkylsulfonyl);
• R4 and R5 which may be the same or different each represent a hydrogen atom, C1-5 alkyl (the C1-5 alkyl is optionally substituted by one to three groups selected from the group consisting of hydroxy, halogen atoms, cyano, C3-7 cycloalkyl, and C1-5 alkoxy), C3-7 cycloalkyl, or a 4- to 8-membered saturated or unsaturated heterocycle containing one or more nitrogen, oxygen or sulfur atoms in the ring (the 4- to 8-membered saturated or unsaturated heterocycle is optionally substituted by one or two groups selected from the group consisting of hydroxy, C1-5 alkyl, C1-5 alkoxy, halogen atoms, cyano, C2-5 alkanoyl, and trifluoromethyl), or
• R4 and R5, together with the adjoining nitrogen atom, form a 4- to 8-membered saturated or unsaturated heterocycle optionally containing one or more nitrogen, oxygen or sulfur atoms in the ring in addition to the adjoining nitrogen atom (the 4- to 8-membered saturated or unsaturated heterocycle is optionally substituted by one or two groups selected from the group consisting of hydroxy, C1-5 alkyl (the C1-5 alkyl is optionally substituted by one or two hydroxyl groups), C1-5 alkoxy, halogen atoms, cyano, C2-5 alkanoyl, oxo, aminocarbonyl, mono-C1-5 alkylaminocarbonyl, di-C1-5 alkylaminocarbonyl, trifluoromethyl, amino, mono-C1-5 alkylamino, di-C1-5 alkylamino and C2-5 alkanoylamino, and the 4- to 8-membered saturated or unsaturated heterocycle optionally has a C1-5 alkylene group crosslinking two different carbon atoms in the ring) or form 2-oxa-6-azaspiro[3.3]hept-6-yl or 7-oxa-2-azaspiro[3.5]non-2-yl;
• the optionally substituted azole ring which is represented by the following formula (α):
• has any one of the structures in the following formula group (II):
• where
• Ry represents a hydrogen atom or C1-5 alkyl;
• X1 and X2 are such that
• i) when X1 is a single bond or the formula —CO—, X2 represents —C1-5 alkylene- or —O—C1-5 alkylene-;
• and
• ii) when X1 is the formula —CONRx1, X2 represents a single bond;
• Rx1 represents a hydrogen atom or C1-5 alkyl;
• and
• the ring A represents a benzene ring, a 6-membered aromatic heterocycle (the benzene ring and the 6-membered aromatic heterocycle are optionally substituted by one or two groups selected from the group consisting of halogen atoms and C1-5 alkoxy), a 4- to 8-membered saturated or partially unsaturated heterocycle containing one or two nitrogen atoms (the 4- to 8-membered saturated or unsaturated heterocycle is optionally substituted by one oxo) or C3-7 cycloalkane] or a pharmaceutically acceptable salt of the azole derivative.